Identification and Characterization of a B-Raf Kinase Alpha Helix Critical for the Activity of MEK Kinase in MAPK Signaling
D. Nguyen, L. Y. Lin, J. Zhou, E. Kibby, T. Sia, T. Tillis, N. Vapuryan, M.-R. Xu, R. Potluri, Y. Shin, E. Erler, N. Bronkema, D. Boehmler, C. Chung, C. Burkhard, , D. Fera
The paper identifies an alpha helix on B-Raf critical for its interaction with MEK and oncogenic activity, suggesting it as a potential drug target for melanoma treatment.
bioRxiv · Jul 19, 2020 · PreprintBiochemistry