A. Bartesaghi

Molecular architecture and conservation of an immature human endogenous retrovirus

The paper determines the structure of immature HERV-K VLPs using cryoET STA, revealing conserved assembly mechanisms across retroviruses.

Structures of trehalose-6-phosphate synthase, Tps1, from the fungal pathogen Cryptococcus neoformans: a target for novel antifungals

This paper reports the cryo-EM structures of CnTps1 from Cryptococcus neoformans in unliganded and ligand-bound forms, revealing substrate-binding residues and tetramer stabilization, with implications for antifungal drug design.

Accurate Detection of Proteins in Cryo-Electron Tomograms from Sparse Labels

This paper introduces a particle detection framework for cryo-electron tomograms that improves detection accuracy with minimal labeling and faster training.

Structural basis for breadth development in a HIV-1 neutralizing antibody

This paper determines structures of HIV-1 antibodies at different stages of maturation to understand how neutralization breadth develops through affinity optimization.

Automated systematic evaluation of cryo-EM specimens with SmartScope

SmartScope automates cryo-EM specimen evaluation using deep learning, improving efficiency and reducing manual effort in structure determination.

Redox sensitive E2 Rad6 controls cellular response to oxidative stress via K63 ubiquitination of ribosomes.

The paper identifies Rad6 as a redox-sensitive E2 enzyme that modifies ribosomes with K63 ubiquitin during oxidative stress, linking it to translation control and stress response.

Beam image-shift accelerated data acquisition for near-atomic resolution single-particle cryo-electron tomography

This paper introduces BISECT, a method that accelerates cryo-electron tomography data acquisition and improves resolution by using beam-image shift and advanced processing techniques.

Fab-dimerized glycan-reactive antibodies neutralize HIV and are prevalent in humans and rhesus macaques

The paper identifies Fab-dimerized glycan-reactive antibodies in HIV-infected macaques and HIV-naïve humans that neutralize HIV-1 and can be elicited by vaccination.

Disruption of the HIV-1 Envelope allosteric network blocks CD4-induced rearrangements

This study identifies a critical role for W571 in HIV-1 Env allostery by showing mutations disrupting CD4-induced rearrangements and rendering Env insensitive to CD4 binding.