T. H. Hampton

The paper analyzes Pseudomonas aeruginosa gene expression in CF sputum and identifies metal restriction as a key driver of gene expression variation across donors.

This paper develops a novel in vitro culture medium, CF-MiPro, that mimics the CF gut environment and alters non-CF microbiomes to resemble CF-like profiles.

This paper uses random forest algorithms to predict clinical outcomes in children with cystic fibrosis based on stool microbiota composition.

This study develops a polymicrobial biofilm model of the CF lung to investigate community-specific antimicrobial resistance and identifies LasR loss-of-function as a driver of tobramycin tolerance through increased phenazine production.

This study tracks the development of the gut microbiome in children with cystic fibrosis from birth to age 4, finding persistent dysbiosis and early signs of inflammatory bowel disease-associated microbiota.

This paper demonstrates that TecA, a type VI secretion system effector of Burkholderia cenocepacia, acts as a virulence factor by exacerbating lung inflammation, weight loss, and lethality in a CF mouse model.

The paper identifies five bacterial community types in CF patients and finds that community instability is linked to worse lung function outcomes.

This study shows that zinc availability affects the growth dynamics between Streptococcus sanguinis and Pseudomonas aeruginosa in co-culture, with lower zinc levels favoring Streptococcus and higher levels favoring Pseudomonas.