The paper shows an IL-2 mutein expands regulatory T cells that enhance IL-10 and CTLA-4 to suppress dendritic cells, reducing autoimmunity in NOD mice.

bioRxiv · Dec 1, 2023 · PreprintImmunology

Chromatin conformation dynamics during CD4+ T cell activation implicates autoimmune disease-associated genes and regulatory elements

M. C. Pahl, P. Sharma, R. M. Thomas, Z. Thompson, Z. Mount, J. Pippin, P. A. Morawski, C. Su, D. J. Campbell, S. F. Grant, A. D. Wells

The paper identifies autoimmune disease-associated genes and regulatory elements by analyzing chromatin dynamics during CD4+ T cell activation using RNA-seq, ATAC-seq, and HiC.

bioRxiv · Apr 5, 2023Immunology

Designed proteins assemble antibodies into modular nanocages

R. Divine, H. V. Dang, G. Ueda, J. A. Fallas, I. Vulovic, W. Sheffler, S. Saini, Y. T. Zhao, I. X. Raj, P. A. Morawski, M. F. Jennewein, L. J. Homad, Y.-H. Wan, M. R. Tooley, F. Seeger, , D. Baker

The paper designs modular nanocages that assemble antibodies into precise geometries, enhancing signaling and neutralization compared to free antibodies.

bioRxiv · Dec 1, 2020Biochemistry

The COVID-19 immune landscape is dynamically and reversibly correlated with disease severity

H. Bolouri, C. Speake, D. Skibinski, S. A. Long, A. M. Hocking, D. J. Campbell, J. A. Hamerman, U. Malhotra, J. H. Buckner, BRI COVID-19 Research Team

This study identifies three immune clusters in COVID-19 patients correlated with disease severity and shows that immune responses change dynamically with clinical outcomes.

bioRxiv · Sep 18, 2020Immunology

ICOS signaling limits regulatory T cell accumulation and function in visceral adipose tissue

K. L. Mittelsteadt, E. T. Hayes, D. J. Campbell

The paper shows that ICOS signaling limits regulatory T cell accumulation and function in visceral adipose tissue, reducing inflammation and improving insulin sensitivity.

bioRxiv · Jun 1, 2020Immunology

A novel humanized mouse model to study the function of human cutaneous memory T cells in vivo in human skin

M. M. Klicznik, A. Benedetti, L. M. Gail, S. R. Varkhande, R. Holly, M. Laimer, A. Stoecklinger, A. Sir, R. Reitsamer, T. Neuper, J. Horejs-Hoeck, M. D. Rosenblum, D. J. Campbell, E. Murauer, I. K. Gratz

This study develops a humanized mouse model to study human cutaneous memory T cells in vivo, showing their functional profiles and responses to pathogens.

bioRxiv · May 15, 2020Immunology

Transcriptomic profiling of human effector and regulatory T cell subsets identifies predictive population signatures

B. Hoellbacher, T. Duhen, S. Motley, M. M. Klicznik, I. K. Gratz, D. J. Campbell

The paper identifies transcriptional signatures of human Th and Treg cell subsets and shows their enrichment in different tissues using bulk RNA-seq data.

bioRxiv · May 13, 2020Immunology

Regulatory T cell expansion by a highly CD25-dependent IL-2 mutein arrests ongoing autoimmunity

L. Khoryati, M. N. Pham, M. Sherve, S. Kumari, K. Cook, J. Pearson, M. Bogdani, D. J. Campbell, M. A. Gavin

A CD25-dependent IL-2 mutein selectively expands regulatory T cells and provides potent and targeted control of autoimmunity.

bioRxiv · May 10, 2020 · PreprintImmunology

Treg cells maintain selective access to IL-2 and immune homeostasis despite substantially reduced CD25 function

E. T. Hayes, C. E. Hagan, D. J. Campbell

This study shows Treg cells maintain selective IL-2 signaling despite reduced CD25 function, preventing immune dysregulation.

bioRxiv · Dec 24, 2019Immunology