S. Saini

Perinatal Nicotine Exposure Disrupts Hematopoietic Stem Cell Development and Elevates Influenza Susceptibility in Adulthood

Adaptive and pleiotropic effects of evolution in synonymous sugar environments.

This study shows that adaptation to similar environments leads to unpredictable adaptive responses but predictable pleiotropic effects based on ancestral fitness.

Empirical evidence of resource dependent evolution of payoff matrices in Saccharomyces cerevisiae populations.

This study provides empirical evidence of resource-dependent changes in payoff matrices of Saccharomyces cerevisiae populations, showing three distinct evolutionary outcomes based on carbon source and genotypes.

Maintenance of cooperation in a yeast population in a public-good driven system.

This study shows that cooperators in a yeast population increase in fitness over time in a public-good system, due to increased privatization of the carbon resource.

When is sympatric speciation a possible evolutionary outcome?

This paper investigates conditions under which sympatric speciation can occur by modeling adaptation for resource utilization and analyzing prezygotic and postzygotic barriers.

Rapid evolution of pre-zygotic reproductive barriers in allopatric populations.

This study shows that pre-zygotic reproductive barriers can evolve rapidly in allopatric yeast populations due to natural selection or genetic drift.

Inhibition of LATS Kinases in Ovarian Cancer Activates Cyclin D1/CDK4 and Decreases DYRK1A Activity

This study shows that inhibiting LATS kinases in ovarian cancer cells activates cyclin D1/CDK4 and reduces DYRK1A activity, promoting tumor growth.

The chromatin associated Sin3B is a critical regulator of DNA damage repair through the engagement of the Non-Homologous End Joining.

This study shows Sin3B is critical for DNA damage repair by promoting non-homologous end joining through MDC1 recruitment, highlighting its role in genomic integrity and potential as a cancer therapeutic target.

Plausible Mechanistic Insights in Biofilm Eradication Potential of against Candida spp. using In Situ Synthesized Tyrosol Functionalized Chitosan Gold Nanoparticles as a versatile Antifouling Coating on Implant Surfaces

This study evaluates the antifungal and antibiofilm effects of tyrosol functionalized chitosan gold nanoparticles against Candida species and identifies mechanisms of action.

Public-good driven release of heterogeneous resources leads to genotypic diversification of an isogenic yeast population in melibiose.

This study shows that an isogenic yeast population diversifies when grown on melibiose due to mutations in the GAL3 gene, which drives the release of a public good enzyme.

Recombinant binder of sperm protein1 (rec-BSP1) as a potent fertility factor mediates its effect on embryo production

This study optimizes the production of rec-BSP1 and demonstrates its ability to enhance buffalo sperm motility and blastocyst production in vitro.

Selection in a growing bacterial/yeast colony biases results of mutation accumulation experiments.

This study shows that selection in growing bacterial colonies biases mutation accumulation experiments, affecting mutation rate estimates and the distribution of fitness effects.

Designed proteins assemble antibodies into modular nanocages

The paper designs modular nanocages that assemble antibodies into precise geometries, enhancing signaling and neutralization compared to free antibodies.

F-domain valency determines outcome of signaling through the angiopoietin pathway

The paper investigates how the valency of F-domain scaffolds affects signaling through the angiopoietin pathway, finding that higher valency mimics Ang1's pro-angiogenic effects while lower valency mimics Ang2's antagonistic effects.

Laboratory evolution of anticipatory gene regulation in Escherichia coli.

This study shows that anticipatory gene regulation evolves in E. coli when exposed to cyclical environmental cues, enhancing fitness in alternating conditions.

Evolution of multicellularity and unicellularity in yeast S. cerevisiae to study reversibility of evolutionary trajectories.

This study examines the evolution and reversal of multicellularity in yeast, finding that phenotypic reversal does not mirror the original evolutionary trajectory.

SHORT TERM EVOLUTIONARY DYNAMICS OF ESCHERICHIA COLI IN DIFFERENT CARBON ENVIRONMENTS

This study evolves E. coli in different carbon environments and finds that growth improvements are not due to specialized adaptations but rather general genomic changes affecting lag phase and growth rate.