Locally secreted BiTEs complement CAR T cells by enhancing solid tumor killing
Y. Yin, J. Rodriguez, N. Li, R. Thokala, M. P. Nasrallah, L. Hu, L. Zhang, J. V. Zhang, D. Kainth, L. Haddad, E. X. Johns, Y. Long, H. Liang, J. Qi, X. Zhang, , D. M. O'Rourke
This study shows that BiTE-secreting T cells outperform CAR T cells in killing glioma cells in vitro and in vivo, with enhanced cytotoxicity and tumor growth delay.
bioRxiv · Jun 8, 2021 · PreprintCancer Biology