Synthetic lethality between TP53 and ENDOD1
Z. Tang, M. Zeng, X. Wang, C. Gao, P. Yue, X. Zang, H. Lou, J. Chen, D. Mu, D. Kong, A. Carr, C. Liu
This study identifies synthetic lethality between ENDOD1 and TP53, showing that their combined loss causes DNA damage and cell death, suggesting ENDOD1 as a cancer therapeutic target.
bioRxiv · Oct 14, 2020Cancer Biology