Author

H. Lou

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Cancer Biology· 3 Bioengineering· 1 Plant Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:human· 6 Research Focus:cancer & tumor microenvironment· 4 Assay:proteomics· 3 Assay:whole-genome sequencing· 3 Research Focus:cell type annotation· 2 Assay:DNA methylation· 2 Research Focus:drug response / drug discovery· 2

Frequent Co-Authors

E. Alvirez· 2 shared E. Gharzouzi· 2 shared H. Lu· 2 shared J. F. Boland· 2 shared L. Mirabello· 2 shared M. Dean· 2 shared M. Yeager· 2 shared N. Wang· 2 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersCancer Biology

E. Alvirez

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Proximity proteomics reveals UCH-L1 as an NLRP3 interactor that modulates IL-1β production in human macrophages and microglia

Z. Liang, A. Damianou, I. Vendrell, E. Jenkins, F. H. Lassen, S. J. Washer, G. Liu, G. Yi, H. Lou, F. Cao, X. Zheng, R. Fernandes, T. Dong, E. W. Tate, E. D. Daniel, B. M. Kessler

The paper identifies UCH-L1 as an NLRP3 interactor that modulates IL-1β production in human macrophages and microglia through proximity proteomics and functional assays.

bioRxiv · Oct 9, 2023 · PreprintBiochemistry

Kinetics and efficacy of antibody drug conjugates in 3D tumour models

C. S. P. Chaundler, H. Lu, R. Fu, N. Wang, H. Lou, G. Serrano de Almeida, L. M. Hadi, E. Aboagye, S. Ghaem-Maghami

This study evaluates ADC efficacy in 3D tumor models, finding that spheroids are less sensitive to ADCs than monolayers, but ADCs can fully penetrate within 24h.

bioRxiv · Feb 14, 2023 · PreprintBiochemistry

Development and optimisation of cationic lipid nanoparticles for mRNA delivery

D. Yan, H. Lu, A. K. Bhamra, R. Fu, N. Wang, J. H. Teh, H. Lou, R. Chen, E. O. Aboagye

This study develops and optimises cationic lipid nanoparticles for mRNA delivery in ovarian cancer cells, achieving 62% encapsulation efficiency and 9.4-fold transfection luminescence.

bioRxiv · Feb 7, 2023 · PreprintBioengineering

Chromosome-level genome assembly of Torreya grandis provides insights into the origin and evolution of gymnosperm-specific sciadonic acid biosynthesis

H. Lou, L. Song, X. Li, W. Chen, Y. Gao, S. Zheng, Z. Fei, X. Sun, J. Wu

The paper presents a chromosome-level genome assembly of T. grandis and identifies genes responsible for gymnosperm-specific sciadonic acid biosynthesis.

bioRxiv · Oct 28, 2022Plant Biology

Extrachromosomal Amplification of Human Papillomavirus Episomes as a Mechanism of Cervical Carcinogenesis

N. M. Rossi, J. Dai, Y. Xie, H. Lou, J. F. Boland, M. Yeager, R. Orozco, E. Alvirez, L. Mirabello, E. Gharzouzi, M. Dean

The paper identifies extrachromosomal HPV16 episomes as a mechanism of cervical carcinogenesis, showing that they can cause cancer without integration through rearranged and multimer episomes.

bioRxiv · Oct 22, 2021 · PreprintCancer Biology

Synthetic lethality between TP53 and ENDOD1

Z. Tang, M. Zeng, X. Wang, C. Gao, P. Yue, X. Zang, H. Lou, J. Chen, D. Mu, D. Kong, A. Carr, C. Liu

This study identifies synthetic lethality between ENDOD1 and TP53, showing that their combined loss causes DNA damage and cell death, suggesting ENDOD1 as a cancer therapeutic target.

bioRxiv · Oct 14, 2020Cancer Biology

The acetyltransferase Eco1 elicits cohesin dimerization during S phase

D. Shi, S. Zhao, M.-Q. Zuo, J. Zhang, W. Hou, M. Dong, Q. Cao, H. Lou

This study shows that Eco1-mediated acetylation promotes cohesin dimerization during S phase, which is regulated by Hos1 and Wpl1.

bioRxiv · Feb 7, 2020Biochemistry

Human papillomavirus 16 positive cervical cancer in Guatemala: The D2 and D3 sublineages differ in integration rate and age of diagnosis

H. Lou, J. F. Boland, E. Torres-Gonzalez, A. Albanez, W. Zhou, M. Steinberg, L. Diaw, J. Mitchell, D. Roberson, M. Cullen, L. Garland, S. Bass, R. Burk, M. Yeager, N. Wentzensen, , M. Dean

This study compares HPV16 D2 and D3 sublineages in Guatemalan cervical cancer samples, finding differences in integration rates, age of diagnosis, and somatic mutation frequency.

bioRxiv · Jan 7, 2020Cancer Biology