Z. Tang

Metabolomics profiling reveals association of fermented herbal feed additive, growth performance and gut microbiota in piglets

This study shows that fermented Chinese medicine (FCM) improves piglet growth and health by increasing lactic acid and propionic acid levels and altering gut microbiota composition.

The WAVE complex forms linear arrays at negative membrane curvature to instruct lamellipodia formation.

This study shows the WAVE complex forms linear arrays at negative membrane curvature to instruct lamellipodia formation through in vivo biochemical approaches.

AB-free kava enhances resilience against the adverse health effects of tobacco smoke in mice

This study evaluates AB-free kava's effects on tobacco smoke-exposed mice, showing it mitigates health deficits with safety, suggesting potential for reducing tobacco-related harm.

SLC13A2-transported citrate is a metabolic signal for PKM2 acetylation and degradation to suppress tumor growth

This paper identifies SLC13A2-transported citrate as a metabolic signal that promotes PKM2 acetylation and degradation, thereby suppressing tumor growth in hepatocellular carcinoma.

Single-cell RNA sequencing reveals recruitment of the M2-like CCL8high macrophages in Lewis lung carcinoma-bearing mice following hypofractionated radiotherapy

This study uses single-cell RNA sequencing to show hypofractionated radiotherapy recruits CCL8high macrophages, reprograms them to an immunosuppressive state, and enhances tumor growth, which can be counteracted by CCL inhibitor Bindarit.

Structural and Biological Evaluations of a Non-Nucleoside STING Agonist Specific for Human STINGA230 Variants

The paper characterizes BDW568, a non-nucleoside STING agonist, showing it activates STINGA230 variants in human cells and mimics endogenous ligands.

Chemical-guided SHAPE sequencing (cgSHAPE-seq) informs the binding site of RNA-degrading chimeras targeting SARS-CoV-2 5' untranslated region

The paper develops cgSHAPE-seq to identify RNA-binding sites of coumarin derivatives targeting SARS-CoV-2 5' UTR and demonstrates their use as RNA-degrading chimeras to reduce viral RNA expression.

Analysis of clinical manifestations and risk factors of HIV-1 associated thrombocytopenia in a general teaching hospital in western China

This study examines the prevalence and risk factors of HIV-1 associated thrombocytopenia and its link to neuroinflammation in a hospital in western China.

A bioinformatics approach to systematically analyze the molecular patterns of monkeypox virus-host cell interactions

This study analyzes monkeypox virus-host cell interactions using transcriptome data to identify signaling pathways, biomarkers, and potential drug candidates.

Mechanistic basis for targeting homologous recombination defective liver cancer via synthetic lethality

This study identifies a novel subtype of HRD in HBVHCC caused by CDW19S perturbation and shows it can be targeted therapeutically.

The radio-protective effects of (-)-Epigallocatechin-3-gallate (EGCG): regulating macrophage function in radiation-induced intestinal injury.

This study shows EGCG protects against radiation-induced intestinal injury by preserving macrophages and gut microbiota, reducing inflammation and improving survival in mice.

Heat Shock Factor 1 (HSF1) specifically potentiates c-MYC-mediated transcription independently of the canonical heat-shock response

This study shows HSF1 enhances c-MYC transcription independently of the heat-shock response by recruiting GCN5 to promote histone acetylation.

Knockout of OsSWEET15 impaired rice embryo formation and seed-setting

This study shows that knocking out OsSWEET15 in rice reduces fertility by impairing embryo formation and seed-setting, with similar effects observed in OsSWEET11 mutants.

BMSC-Derived Exosomal MiRNAs Can Modulate Bone Restoration in Diabetic Rats with Femoral Defects

This study shows that exosomal miR-140-3p from diabetic BMSCs promotes bone restoration in diabetic rats by enhancing osteogenesis and inhibiting the plexin B1 signaling pathway.

Engineered AIM-based Selective Autophagy to Degrade Proteins and Organelles

The paper introduces a method to degrade specific proteins and organelles using engineered autophagy receptors, demonstrating its effectiveness in plant and transient expression systems.

Quantatitive Analysis of Conserved Sites on the SARS-CoV-2 Receptor-Binding Domain to Promote Development of Universal SARS-Like Coronavirus Vaccines

The paper identifies conserved antigenic sites in SARS-CoV-2 and SARS-CoV RBDs and designs RBD variants to improve immunogenicity for universal vaccine development.

Genomic and epigenomic adaptation in SP-R210 (Myo18A) isoform-deficient macrophages

This study investigates how the absence of the SP-R210L isoform in macrophages leads to a hyper-inflammatory state through altered genomic and epigenomic responses.

Deep learning from multiple experts improves identification of amyloid neuropathologies

The paper develops a deep learning model that combines multiple expert annotations to improve the identification of amyloid neuropathologies, achieving consistent diagnoses across varying expert opinions.

Hydraulic diversity stabilizes productivity in a large-scale subtropical tree biodiversity experiment

The paper shows that tree species richness stabilizes forest productivity through increased species asynchrony and hydraulic trait diversity, not community-weighted means.

Caerulomycin and Collismycin Antibiotics Share a trans Flavin-Dependent Assembly Line for 2,2-Bipyridine Formation and Sulfur Fate Differentiation

This paper identifies a shared trans flavin-dependent assembly line for 2,2-bipyridine formation in caerulomycin and collismycin antibiotics, revealing sulfur fate differentiation through differential sulfhydryl group treatment.

Allantoin induces pruritus by activating MrgprD in chronic kidney disease

This study shows allantoin induces pruritus in CKD by activating MrgprD and TRPV1 in DRG neurons.

Co-infection of influenza A virus enhances SARS-CoV-2 infectivity

This study shows that influenza A virus pre-infection increases SARS-CoV-2 infectivity in multiple cell types and worsens lung damage in mice.

Synthetic lethality between TP53 and ENDOD1

This study identifies synthetic lethality between ENDOD1 and TP53, showing that their combined loss causes DNA damage and cell death, suggesting ENDOD1 as a cancer therapeutic target.

CECR2 Drives Breast Cancer Metastasis by Suppressing Macrophage Inflammatory Responses

This study identifies CECR2 as a driver of breast cancer metastasis by suppressing macrophage inflammatory responses, offering a therapeutic target for metastatic disease.

Impact of the radiated brain microenvironment on a panel of human patient-derived xenografts.

This study evaluates how the radiated brain microenvironment affects the growth of nine human glioblastoma cell lines, finding that some tumors grow faster while others grow slower in this environment.

A small molecule that binds an RNA repeat expansion stimulates its decay via the exosome complex

A small molecule binds an RNA repeat expansion, reversing disease defects in DM1 and FECD by either disabling gain-of-function or stimulating exosome-mediated decay.

LanD-like Flavoprotein-Catalyzed Aminovinyl-Cysteine Formation through Oxidative Decarboxylation and Cyclization of a Peptide at the C-Terminus

This paper identifies a dual activity in LanD-like flavoproteins for forming aminovinyl-cysteine residues through oxidative decarboxylation and cyclization of peptides.

Dissemination of linezolid-resistance through sex pheromone plasmid transfer in Enterococcs faecalis

This study identifies sex pheromone plasmids as a mechanism for disseminating linezolid-resistance in E. faecalis through plasmid transfer.

Transcriptional reprogramming in fused cells is triggered by plasma-membrane diminution

The paper shows that cell fusion triggers differentiation through plasma-membrane diminution, leading to transient cell starvation and activation of AMPK, which inhibits YAP1 and causes cell-cycle arrest.

Dissection of ligand-CDK8/CycC unbinding free energy barriers and kinetics by molecular simulations

This paper uses molecular simulations to study ligand-CDK8/CycC unbinding kinetics and free energy barriers, guiding the design of ligands with improved residence time.