Author

D. Nissen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1 Organism:human· 1

Frequent Co-Authors

W. Ma· 3 shared A. L. Hessel· 2 shared M. Kuehn· 2 shared T. C. Irving· 2 shared W. A. Linke· 2 shared A. J. Fenwick· 1 shared B. Palmer· 1 shared D. A. Kass· 1 shared

Activity by Year

2023-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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3 shared papersPhysiology

W. Ma

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Myosin-binding protein C forms C-links and stabilizes OFF states of myosin

A. L. Hessel, N. M. Engels, M. Kuehn, D. Nissen, R. L. Sadler, W. Ma, T. C. Irving, W. A. Linke, S. P. Harris

This study shows that MyBP-CC1C7 domains form C-links and stabilize myosin OFF states, affecting crossbridge kinetics and sarcomere function.

bioRxiv · Sep 10, 2023 · PreprintPhysiology

Right Ventricular Sarcomere Contractile Depression and the Role of Thick Filament Activation in Human Heart Failure with Pulmonary Hypertension

V. Jani, M. I. Aslam, A. J. Fenwick, W. Ma, H. Gong, G. Milburn, D. Nissen, I. M. Cubero Salazar, O. Hanselman, M. Mukherjee, M. K. Halushka, K. B. Margulies, K. Campbell, T. C. Irving, D. A. Kass, S. Hsu

This study identifies contractile deficits in right ventricular myocytes of HFrEF-PH patients, showing reduced calcium-activated tension and altered myosin ATP turnover, with implications for targeted therapies.

bioRxiv · Mar 9, 2023Biophysics

The distinctive mechanical and structural signatures of residual force enhancement in myofibers

A. L. Hessel, M. Kuehn, B. Palmer, D. Nissen, D. Mishra, V. Joumaa, J. Freundt, W. Ma, K. Nishikawa, T. Irving, W. A. Linke

The paper investigates titin's role in residual force enhancement (RFE) in muscle by analyzing structural changes in myofibers with and without titin cleavage and in a mutant strain.

bioRxiv · Feb 19, 2023 · PreprintPhysiology