S. Agrawal

Precision and efficacy of RNA-guided DNA integration in high-expressing muscle loci

This study evaluates CRISPR-based gene integration in skeletal muscle using two high-expressing loci, demonstrating high-level therapeutic gene expression in mouse myoblasts.

Hummingbirds rapidly respond to the removal of vision and control a sequence of rate-commanded maneuvers in milliseconds

This study shows hummingbirds control rapid flight maneuvers using rate-commanded movements and respond to vision loss after a critical time during escape sequences.

Dissecting Multiparametric Cerebral Hemodynamics using Integrated Ultrafast Ultrasound and Multispectral Photoacoustic Imaging

The paper introduces a multimodal imaging platform to measure multiple cerebral hemodynamic parameters with high spatiotemporal resolution and applies it to study brain responses to hypercapnia.

Physiological Responses of The Leaves of a High-Altitude Plant Picrorhiza kurroa to Cold Stress

This study examines physiological changes in Picrorhiza kurroa leaves at different altitudes to understand their response to cold stress.

Genomic evaluation of a case of Lacticaseibacillus rhamnosus endocarditis: comparison with commercial yogurt isolates and examination of global population structure

This paper reports a case of Lacticaseibacillus rhamnosus endocarditis, comparing the patient's isolate to commercial yogurt strains and global genomic data to assess infection source.

Cell-Sized Lipid Vesicles as Artificial Antigen-Presenting Cells for Antigen-Specific T Cell Activation

This study demonstrates artificial antigen-presenting cells (aAPCs) that activate T cells efficiently, showing significant increases in IFN-gamma secretion and T cell expansion without additional stimulants.

Three-dimensional actuation of hummingbird wings requires diverse effects from the primary flight muscles

This study develops a functional model of hummingbird musculoskeletal system to reveal how primary flight muscles generate three-dimensional wing actuation through diverse effects.

A Transparent Ultrasound Array for Real-time Optical, Ultrasound and Photoacoustic Imaging

This paper introduces a transparent ultrasound transducer array that enables real-time multimodal imaging combining ultrasound, photoacoustic, and optical contrasts.

A single cell atlas of human and mouse white adipose tissue

This study creates single-cell atlases of human and mouse white adipose tissue, identifying cell types and their roles in metabolic disease across different body weights and diets.

Binding Affinity Estimation From Restrained Umbrella Sampling Simulations

The paper estimates protein-ligand binding affinity using restrained umbrella sampling simulations and compares results to experimental data.

Stability Comparisons between Natural versus Engineered Archaeal Heat Shock Proteins

This study compares the thermal and acid stability of natural and engineered archaeal heat shock proteins using structural and biochemical assays.

Toxoplasma gondii Toxolysin 4 contributes to efficient parasite egress from host cells

This study identifies Toxolysin 4 (TLN4) as a metalloproteinase necessary for efficient Toxoplasma gondii egress from host cells.

Modeling Combined Ultrasound and Photoacoustic Imaging: Simulations aiding Device Development and Deep Learning

The paper develops a hybrid USPA simulation platform to improve imaging quality by optimizing device parameters and generating datasets for deep learning.

Metabolism of long-chain fatty acids affects disulfide bond formation in Escherichia coli and activates envelope stress response pathways as a combat strategy

This study shows that long-chain fatty acid metabolism in E. coli affects disulfide bond formation and activates envelope stress response pathways to maintain redox homeostasis.

Mechanistic Picture for Monomeric Human Fibroblast Growth Factor 1 Stabilization by Heparin Binding

This study uses molecular dynamics simulations to show how heparin stabilizes hFGF1 by altering its conformational dynamics and electrostatic interactions.

Structure and function of a novel osmoregulated periplasmic fiber-forming high-molecular-weight carbohydrate of Myxococcus xanthus

This paper identifies a novel high-molecular-weight fiber-forming polysaccharide in Myxococcus xanthus that functions as an osmoregulated periplasmic glucan, replacing canonical OPGs and stabilizing the cell envelope during spore formation.

Nephrotic Syndrome-Associated Hypercoagulopathy is Alleviated by Nuclear Receptor Agonist Therapy with both Pioglitazone and Glucocorticoids

This paper shows that pioglitazone and glucocorticoids reduce proteinuria and improve hypercoagulopathy in nephrotic syndrome, both in rats and children.