D. Schindler

Frequent transitions in self-assembly across the evolution of a central metabolic enzyme

The paper investigates the evolutionary dynamics of self-assembly in prokaryotic citrate synthases, finding frequent transitions between different assembly types without strong functional consequences.

T4 phage RNA is NAD-capped and alters the NAD-cap epitranscriptome of Escherichia coli during infection

This study identifies NAD-capped RNAs during T4 phage infection of E. coli, showing dynamic changes in NAD-capping and revealing a phage-encoded Nudix hydrolase involved in NAD-RNA decapping.

Temporal epigenome modulation enables efficient bacteriophage engineering and functional analysis of phage DNA modifications

The paper describes a method to temporarily modulate phage DNA modifications using NgTET, enabling efficient Cas-mediated mutagenesis and functional analysis of phage epigenome.

Identification, structure and function of the methyltransferase involved in the biosynthesis of the dithiolopyrrolone antibiotic xenorhabdin

This study identifies and characterizes XrdM, an amide methyltransferase involved in dithiolopyrrolone antibiotic biosynthesis, and shows it is distinct from DtpM in structure and function.

A supernumerary synthetic chromosome in Komagataella phaffii as a repository for extraneous genetic material

This paper describes a stable linear artificial chromosome in Komagataella phaffii that can carry multiple genes for biomanufacturing without disrupting the native genome.

DNA replication is not a limiting factor for the rapid growth of Vibrio natriegens

The paper investigates whether DNA replication limits the rapid growth of Vibrio natriegens by creating a strain with a single origin of replication, finding no significant change in growth rate.

Differential Regulation of Retinoic Acid Metabolism in Fanconi Anemia

This study identifies differential regulation of retinoic acid metabolism in Fanconi anemia patient cells, linking retinaldehyde to DNA damage and repair defects.

Polygenic mutations model the pleiotropic disease of Fanconi Anemia

This study shows that mutations in two FANC genes in mice model the severity and heterogeneity of Fanconi Anemia, revealing functional synergism of polygenic mutations.