Author

D. Straume

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 8 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Research Focus:cell type annotation· 5 Organism:bacteria (other)· 3 Research Focus:protein folding & dynamics· 3 Research Focus:cell signaling & trafficking· 2 Approach:genetic perturbation / CRISPR· 2 Organism:human· 2 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

L. S. Havarstein· 7 shared M. Kjos· 6 shared G. A. Stamsas· 4 shared J. A. Hermoso· 3 shared J.-W. Veening· 3 shared M. Alcorlo· 3 shared Z. Salehian· 3 shared A. Ruud Winther· 2 shared

Activity by Year

2018-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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7 shared papersMicrobiology

L. S. Havarstein

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

The function of CozE proteins is linked to lipoteichoic acid biosynthesis in Staphylococcus aureus

M. D. Barbuti, E. Lambert, I. S. Myrbraten, A. Ducret, G. A. H. Stamsas, L. Wilhelm, X. Liu, Z. Salehian, J.-W. Veening, D. Straume, C. Grangeasse, C. Perez, M. Kjos

This study identifies CozE proteins as regulators of lipoteichoic acid biosynthesis and membrane homeostasis in Staphylococcus aureus through genetic and biochemical analyses.

bioRxiv · Oct 20, 2023Microbiology

Competence remodels the pneumococcal cell wall providing resistance to fratricide and surface exposing key virulence factors

V. Minhas, A. Domenech, D. Synefiaridou, D. Straume, M. Brendel, G. Cebrero, X. Liu, C. Costa, M. Baldry, J.-C. Sirard, C. Perez, N. Gisch, S. Hammerschmidt, L. S. Havarstein, J.-W. Veening

This study shows that competence in Streptococcus pneumoniae is crucial for virulence by increasing surface exposure of virulence factors and providing resistance to fratricide.

bioRxiv · Aug 3, 2022 · PreprintMicrobiology

SmdA is a novel cell morphology determinant in Staphylococcus aureus

I. S. Myrbraten, G. A. Stamsas, H. Chan, D. Morales Angeles, T. M. Knutsen, Z. Salehian, V. Shapaval, D. Straume, M. Kjos

This study identifies SmdA as a critical membrane protein in Staphylococcus aureus that regulates cell division and affects antibiotic susceptibility.

bioRxiv · Nov 23, 2021Microbiology

EloR interacts with the lytic transglycosylase MltG at midcell in Streptococcus pneumoniae R6.

A. Ruud Winther, M. Kjos, M. Leangen Herigstad, L. S. Havarstein, D. Straume

This paper identifies EloR as a key regulator of cell elongation in Streptococcus pneumoniae by interacting with MltG at midcell to coordinate PG synthesis with division.

bioRxiv · Dec 18, 2020Microbiology

Structural characterization of the essential cell division protein FtsE and its interaction with FtsX in Streptococcus pneumoniae

M. Alcorlo, D. Straume, J. Lutkenhaus, L. S. Havarstein, J. A. Hermoso

This paper reports the high-resolution structures of FtsE from Streptococcus pneumoniae in complex with nucleotides, revealing its ATPase activity and structural plasticity essential for FtsX interaction.

bioRxiv · Jun 8, 2020Biochemistry

Class A PBPs have a distinct and unique role in the construction of the pneumococcal cell wall.

D. Straume, K. Wiaroslawa Piechowiak, S. Olsen, G. A. Stamsas, K. H. Berg, M. Kjos, M. V. Heggenhougen, M. Alcorlo, J. A. Hermoso, L. S. Havarstein

This study identifies a specific role for class A PBPs in processing nascent peptidoglycan synthesized by the divisome in S. pneumoniae.

bioRxiv · Jun 10, 2019Microbiology

Prevention of EloR/KhpA heterodimerization by introduction of site-specific amino acid substitutions renders the essential elongasome protein PBP2b redundant in Streptococcus pneumoniae.

A. Ruud Winther, M. Kjos, G. A. Stamsas, L. S. Havarstein, D. Straume

This paper shows that disrupting EloR/KhpA heterodimerization in S. pneumoniae makes the elongasome redundant, highlighting the complex's role in regulating cell division.

bioRxiv · Oct 6, 2018Microbiology

Structure of the large extracellular loop of FtsX and its interaction with the essential peptidoglycan hydrolase PcsB in Streptococcus pneumoniae

B. E. Rued, M. Alcorlo, K. A. Edmonds, S. Martinez-Caballero, D. Straume, Y. Fu, K. E. Bruce, H. Wu, L. S. Havarstein, J. A. Hermoso, M. E. Winkler, D. P. Giedroc

This study presents the structure of FtsX's extracellular loop and shows its essential interaction with PcsB for cell viability in Streptococcus pneumoniae.

bioRxiv · Oct 2, 2018Microbiology

CozEa and CozEb play overlapping and essential roles in controlling cell division in Staphylococcus aureus

G. A. Stamsas, I. Myrbraten, D. Straume, Z. Salehian, J.-W. Veening, L. S. Havarstein, M. Kjos

This study identifies CozEa and CozEb as essential for cell division in S. aureus, showing they work together with EzrA and are conserved in S. pneumoniae.

bioRxiv · May 23, 2018Microbiology