K. P. Smith

SAXS/MC studies of the mixed-folded protein Cdt1 reveal monomeric, folded over conformations

This study uses biophysical and computational methods to characterize the structure of human Cdt1, revealing 'folded over' conformations that suggest a scaffold function.

An RGB based deep neural network for high fidelity Fusarium head blight phenotyping in wheat

This paper introduces an RGB-based deep neural network for high-fidelity Fusarium head blight phenotyping in wheat, achieving accuracy comparable to human scoring and demonstrating strong generalizability across field conditions.

RenSeq of Silphium integrifolium Reveals a Biotic Gradient for Disease Resistance

This study uses RenSeq to analyze R genes in Silphium integrifolium across a rainfall gradient, finding a positive correlation between precipitation and R gene count.

Selection for seed size has indirectly shaped specialized metabolite abundance in oat (Avena sativa L.)

The paper examines how selection for seed size in oats has influenced the abundance of specialized metabolites, finding uneven effects on different metabolite classes.

Profiling the in vitro and in vivo activity of streptothricin-F against carbapenem-resistant Enterobacterales: a historic scaffold with a novel mechanism of action

This paper evaluates the in vitro and in vivo activity of streptothricin-F against carbapenem-resistant Enterobacterales, identifying its potent activity and novel mechanism of action involving 16S rRNA helix 34.

Development of first linkage map for Silphium integrifolium (Asteraceae) enables identification of sporophytic self-incompatibility locus

The paper develops a linkage map for Silphium integrifolium to identify the sporophytic self-incompatibility locus, successfully mapping it and identifying potential gene candidates.

SARS-CoV2 Testing: The Limit of Detection Matters

This study evaluates how the limit of detection (LoD) of SARS-CoV-2 assays affects false negative rates using 27,500 test results, finding a 13% increase in false negatives per 10-fold LoD increase.

Structural assembly of the human Miro1/2 GTPases based on the crystal structure of the N-terminal GTPase domain

The paper reports the crystal structure of the human Miro1 N-terminal GTPase domain bound to GTP and models the assembly of the full-length soluble domain of Miro1/2.

Trisomy 21 activates the kynurenine pathway via increased dosage of interferon receptors

This study identifies a mechanism by which Trisomy 21 increases kynurenine pathway activity through overexpression of interferon receptors, leading to immunosuppression and neurotoxicity in Down syndrome.