Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
13 papers
Recent·Most cited
E. R. Bring Horvath, W. J. Brazelton, M. C. Kim, R. Cullum, M. A. Mulvey, W. Fenical, J. M. Winter
The paper investigates bacterial diversity and natural product potential in Great Salt Lake sediment, identifying a new Saccharomonospora species and characterizing genomic features of Actinomycetota.
bioRxiv · Nov 7, 2023Ecology
M. Zarei, O. Hajihassani, J. J. Hue, H. J. Graor, L. D. Rothermel, J. M. Winter
This study shows that targeting wild-type IDH1 enhances chemosensitivity in pancreatic cancer by disrupting redox balance and increasing ROS-induced apoptosis.
bioRxiv · Mar 29, 2023Cancer Biology
Y. Ouyang, C. N. Cunningham, J. A. Berg, A. G. Toshniwal, C. E. Hughes, J. G. Van Vranken, M.-Y. Jeong, A. A. Cluntun, G. Lam, J. M. Winter, E. Akdogan, K. K. Dove, S. P. Gygi, C. D. Dunn, D. R. Winge, J. Rutter
The paper shows phosphate starvation increases mitochondrial membrane potential through respiration-independent mechanisms in yeast and mammalian cells.
bioRxiv · Oct 25, 2022Cell Biology
The paper characterizes the biosynthesis of penilumamide A in Aspergillus flavipes and biochemically defines the substrate specificity of a pterin-specific adenylation domain.
bioRxiv · Aug 30, 2022 · PreprintBiochemistry
J. J. Hue, M. Zarei, H. J. Graor, O. Hajihassani, E. S. Katayama, A. W. Loftus, A. Vaziri-Gohar, J. M. Winter
The paper provides detailed surgical techniques for orthotopic and splenic injections in a murine model of pancreatic cancer to improve preclinical research accuracy.
bioRxiv · Jul 30, 2022 · PreprintCancer Biology
M. Zarei, O. Hajihassani, J. J. Hue, H. J. Graor, M. Rathore, A. Vaziri-Gohar, J. M. Asara, J. M. Winter, L. D. Rothermel
This study shows that inhibiting wild-type IDH1 enhances chemotherapy response in melanoma by reducing redox homeostasis and increasing reactive oxygen species.
bioRxiv · May 13, 2022Cancer Biology
P. Zhang, G. Wu, S. C. Heard, C. Niu, S. A. Bell, F. Li, Y. Ye, Y. Zhang, J. M. Winter
The paper identifies a tnd biosynthetic cluster in Aspergillus flavipes and characterizes a bifunctional diterpene synthase, leading to the discovery of talarodiene and its transformation into talaronoid C.
bioRxiv · May 3, 2022 · PreprintBioengineering
A. Vaziri-Gohar, J. J. Hue, H. J. Graor, A. Abbas, M. Zarei, O. Hajihassani, G. Titomihelakis, J. Feczko, M. Rathore, R. Wang, M. Zarei, M. Goudarzi, R. Zhang, B. Willard, L. Zhang, , J. M. Winter
This study shows that high glucose levels increase the effectiveness of chemotherapy in pancreatic cancer by reducing glutathione biosynthesis, which enhances oxidative stress in cancer cells.
bioRxiv · Apr 29, 2022Cancer Biology
K. G. Hicks, A. A. Cluntun, H. L. Schubert, S. R. Hackett, J. A. Berg, P. G. Leonard, M. A. Ajalla Aleixo, A. Blevins, P. Barta, S. Tilley, S. Fogarty, J. M. Winter, H.-C. Ahn, K. N. Allen, S. Block, , J. Rutter
The paper develops the MIDAS platform to identify protein-metabolite interactions, revealing novel regulatory mechanisms in carbohydrate metabolism.
bioRxiv · Aug 28, 2021 · PreprintBiochemistry
J. M. Winter, H. L. Fresenius, H. R. Keys, C. N. Cunningham, J. Ryan, D. Sirohi, J. A. Berg, S. R. Tripp, P. Barta, N. Agarwal, A. Letai, D. M. Sabatini, M. L. Wohlever, J. Rutter
The paper shows that co-deletion of ATAD1 with PTEN makes cancer cells more susceptible to apoptosis via BIM activation, correlating with better patient survival.
bioRxiv · Jul 1, 2021 · PreprintCancer Biology
A. Vaziri-Gohar, J. J. Hue, H. J. Graor, E. Prendergast, V. Chen, J. Cassel, F. S. Mohammed, A. Abbas, K. Dukleska, I. Khokhar, O. Hajhassani, M. Zarei, R. Wang, L. D. Rothermel, I. Bederman, , J. M. Winter
This study shows that wild-type IDH1 is a metabolic target in pancreatic cancer cells under nutrient limitation, and FDA-approved drugs can inhibit it effectively in preclinical models.
bioRxiv · Nov 19, 2020 · PreprintCancer Biology
E. Nuebel, J. T. Morgan, S. Fogarty, J. M. Winter, S. Lettlova, J. A. Berg, Y.-C. Chen, C. U. Kidwell, J. A. Maschek, K. J. Clowers, C. Argyriou, L. Chen, I. Wittig, J. E. Cox, M. Roh-Johnson, , J. Rutter
The paper investigates peroxisomal dysfunction in Zellweger Spectrum Disease and shows that overexpressing ATAD1 restores mitochondrial function in patient-derived fibroblasts.
bioRxiv · Sep 19, 2020 · PreprintCell Biology
J. P. Torres, Z. Lin, J. M. Winter, P. J. Krug, E. W. Schmidt
The paper shows animals can synthesize complex polyketides, previously thought to be microbial, through a symbiotic partnership with chloroplasts.
bioRxiv · Sep 10, 2019Biochemistry