Immunogenicity of non-canonical HLA-tumor ligands identified through proteogenomics
M. Lozano-Rabella, A. Garcia-Garijo, J. Palomero, A. Yuste-Estevanez, F. Erhard, J. Martin-Liberal, M. Ochoa de Olza, I. Matos, J. J. Gartner, M. Ghosh, F. Canals, A. Vidal, J. M. Piulats, X. Matias-Guiu, I. Brana, , A. Gros
The paper investigates the immunogenicity of non-canonical HLA-I ligands from tumor cells and finds they are not recognized by autologous T-cells but can be targeted by donor T-cells, suggesting potential as immunotherapy targets.
bioRxiv · Nov 7, 2022Cancer Biology