N. Prats

The efficacy of chemotherapy is limited by intratumoural senescent cells that persist through the upregulation of PD-L2

This study identifies PD-L2 as a marker of therapy-induced senescent cells that suppress chemotherapy efficacy, showing PD-L2 blockade enhances tumour remission in mice.

Iron accumulation drives fibrosis, senescence, and the senescence-associated secretory phenotype

The paper shows iron accumulation drives fibrosis, senescence, and SASP in mice and humans, and demonstrates MRI can detect fibrotic burden.

Induction of senescence renders cancer cells highly immunogenic

This study shows that inducing senescence in cancer cells enhances their immunogenicity, leading to stronger anti-tumor immune responses compared to immunogenic cell death.

Multi-omic rejuvenation of naturally aged tissues by a single cycle of transient reprogramming

This study shows that a single cycle of transient OSKM expression reverses aging-related DNA methylation, transcriptional, and metabolic changes in multiple tissues of aged mice.