E. Ghosn

Human Bone Marrow Plasma Cell Atlas: Maturation and Survival Pathways Unraveled by Single Cell Analyses

The study maps human bone marrow plasma cell heterogeneity using single-cell transcriptomics, revealing maturation pathways and molecular features of long-lived plasma cells.

Stromal STAT5-mediated trophic activity regulates hematopoietic multipotent progenitor niche factors

This study shows that STAT5ab in stromal cells regulates niche factors critical for hematopoietic progenitor maintenance and function.

Inactivation of SARS Coronavirus 2 and COVID-19 patient samples for contemporary immunology and metabolomics studies

This paper demonstrates optimal viral inactivation methods for SARS-CoV-2 and COVID-19 patient samples to enable safe handling at lower biosafety levels while preserving downstream assay fidelity.

Pathogenic neutrophilia drives acute respiratory distress syndrome in severe COVID-19 patients

The paper identifies pathogenic neutrophilia as a driver of acute respiratory distress syndrome in severe COVID-19 patients, highlighting IL-8/CXCR2-mediated neutrophil recruitment and hyperinflammation.

Protracted yet coordinated differentiation of long-lived SARS-CoV-2-specific CD8+ T cells during COVID-19 convalescence

The paper characterizes the long-term differentiation of SARS-CoV-2-specific CD8+ T cells in convalescent donors, showing coordinated evolution with other immune components over six months.

Hematopoietic stem cell requirement for macrophage regeneration is tissue-specific

The paper shows that hematopoietic stem cells (HSCs) are required for regeneration of peritoneal macrophages but not brain microglia.

SARS-CoV-2-specific T cells exhibit unique features reflecting robust helper function, lack of terminal differentiation, and high proliferative potential

The paper characterizes SARS-CoV-2-specific T cells in recovered patients, finding they exhibit robust helper function, reduced terminal differentiation, and high proliferative potential.