T. Ma

RGS10 deficiency facilitates distant metastasis by inducing epithelial-mesenchymal transition in breast cancer

This study shows RGS10 deficiency promotes breast cancer metastasis via EMT by mechanisms involving lipocalin-2 and miR-539-5p.

Ribonanza: deep learning of RNA structure through dual crowdsourcing

The paper introduces RibonanzaNet, a deep learning model trained on crowdsourced RNA chemical mapping data to predict RNA structure and related properties.

Distinct sets of molecular characteristics define tumor-rejecting neoantigens

The paper identifies molecular features of tumor-rejecting neoantigens in cSCC and shows how they differ from non-immunogenic neoantigens.

3D-Printable Non-invasive Head Immobilization System for Non-Human Primates

This paper introduces a 3D-printable non-invasive head immobilization system for macaques, showing comparable gaze precision and accuracy to traditional headposts.

Mechanics limit ecological diversity and promote heterogeneity in confined bacterial communities

This study shows that mechanical interactions and spatial constraints in confined environments limit bacterial community diversity but allow stable heterogeneous populations, even with growth advantages.

Transdifferentiation of fibroblasts into muscle cells to constitute cultured meat with tunable intramuscular fat deposition

This study transdifferentiates chicken fibroblasts into muscle cells with tunable fat deposition to create cultured meat mimics with controllable intramuscular fat content.

Pharmacologically inducing regenerative cardiac cells by small molecule drugs

This study shows that a two-drug combination induces regenerative cardiac cells from cardiomyocytes in vitro and in vivo, improving heart function after injury.

PSTPIP2 ameliorates aristolochic acid nephropathy by suppressing interleukin-19-mediated neutrophil extracellular trap formation

This study shows PSTPIP2 reduces kidney damage in AAN by suppressing IL-19-mediated NET formation and inflammation.

The super-pangenome of Populus unveil genomic facets for adaptation and diversification in widespread forest trees

The paper constructs a super-pangenome of 19 Populus species to explore genomic factors driving adaptation and diversification in forest trees.

Post-acute immunological and behavioral sequelae in mice after Omicron infection

This study investigates post-acute immunological and behavioral effects in mice after Omicron infection, showing vaccination reduces pulmonary immune perturbations and behavioral deficits.

The myocyte Nfe2l1-ubiquitin-proteasome system controls muscle fiber type and obesity-induced insulin resistance

This study shows that Nfe2l1 regulates skeletal muscle proteostasis and function, with its loss causing muscle fiber type switching and insulin resistance in high-fat diet conditions.

Long COVID manifests with T cell dysregulation, inflammation, and an uncoordinated adaptive immune response to SARS-CoV-2

This study identifies T cell dysregulation, inflammation, and mis-coordinated adaptive immune responses in Long COVID patients compared to non-LC individuals.

Dopamine promotes Klebsiella quasivariicola proliferation and inflammatory response in the presence of macrophages

This study shows dopamine promotes Klebsiella quasivariicola growth and inflammation in macrophage co-culture, exacerbating lung injury in mice.

Spatial exclusion leads to tug-of-war ecological dynamics between competing species within microchannels

This paper extends the Moran model to include spatial exclusion in microchannels, showing it alters fixation probabilities and fixation times compared to classical models.

Phylogenomics reveals patterns of ancient hybridization and differential diversification contributing to phylogenetic conflict in Populus L. and Salix L.

This study uses phylogenomic analysis to identify ancient hybridization and differential diversification as sources of phylogenetic conflict in Populus and Salix.

Effects of cardiac function alterations on the risk of postoperative thrombotic complications in patients receiving endovascular aortic repair

This study uses a computational model to show that ventricular systolic function affects thrombus formation after EVAR, with specific correlations identified.

Flow-induced mechanical coupling between perinuclear actin cap and nucleus governs spatiotemporal regulation of YAP transport

This study investigates how flow-induced mechanical forces regulate YAP nucleocytoplasmic transport through actin cap formation and nuclear stiffness changes, revealing a unified mechanism linking mechanical stimulation to transcriptional regulation.

HSPB1 facilitates chemoresistance through inhibiting ferroptotic cancer cell death and regulating NF-κB signaling pathway in breast cancer

This study identifies HSPB1 as a driver of chemoresistance in breast cancer by inhibiting ferroptosis and activating NF-κB signaling.

A vast space of compact strategies for highly efficient decisions

The paper explores the space of behavioral policies for decision-making in dynamic environments, showing that non-Bayesian strategies can outperform Bayesian ones and are connected through key mutations.

The Hypoxia-regulated Ectonucleotidase CD73 is a Host Determinant of HIV Latency

This study identifies CD73 as a marker of HIV latency, showing hypoxia enhances its expression and adenosine signaling promotes viral quiescence.

Autophagy Increases Occludin Levels to Enhance Intestinal Paracellular Tight Junction Barrier.

This study shows autophagy increases occludin levels, enhancing intestinal tight junction barrier function through ERK1/2 MAPK signaling.

CyTOF-Lec: Single-cell glycomics analysis reveals glycan features defining cells differentially susceptible to HIV

This study develops CyTOF-Lec to analyze glycan features in human immune cells, revealing that sialic acid levels distinguish HIV-susceptible memory CD4+ T cells.

A pair of transporters controls mitochondrial Zn2+ levels to maintain mitochondrial homeostasis

The paper identifies two transporters that regulate mitochondrial Zn2+ levels in C. elegans, showing their roles in maintaining mitochondrial homeostasis.

Highly potent photoinactivation of bacteria using a water soluble, cell permeable, DNA-binding photosensitizer

This paper demonstrates that Br-DAPI, a DNA-binding photosensitizer, effectively eradicates both gram-negative and gram-positive bacteria through ROS-mediated cell death at low concentrations and light doses.

SARS-CoV-2 receptor ACE2 identifies immuno-hot tumors in breast cancer

This study identifies ACE2 as a marker of immuno-hot tumors in breast cancer by analyzing its expression and correlation with immune features across multiple datasets.

Protracted yet coordinated differentiation of long-lived SARS-CoV-2-specific CD8+ T cells during COVID-19 convalescence

The paper characterizes the long-term differentiation of SARS-CoV-2-specific CD8+ T cells in convalescent donors, showing coordinated evolution with other immune components over six months.

Precision Genome and Base Editing by Regulating mRNA Nuclear Export Using Selective Inhibitors of Nuclear Export

This study identifies SINEs as inhibitors of CRISPR-Cas9 activity by blocking Cas9 mRNA nuclear export, enhancing genome and base editing specificity in human cells.

Antifungal effects of alantolactone on Candida albicans: an in vitro study

This study shows alantolactone has antifungal effects against Candida albicans by inhibiting adhesion, biofilm formation, and cell membrane permeability.

Environmental conditions and diffusion-limited microbial transfer drive specific microbial communities detected at different sections in oil-production reservoir with water-flooding

This study examines microbial community distribution in oil-production reservoirs, finding that environmental variation and diffusion-limited transfer shape distinct communities in different sections.

MiRNA-223 Inhibits MouseGallstone Formation by Targeting Key Transporters in Hepatobiliary Cholesterol Secretion Pathway

This study shows that miRNA-223 inhibits gallstone formation in mice by targeting ABCG5 and ABCG8, key transporters in the bile cholesterol secretion pathway.