Author

N. Hawkey

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Assay:proteomics· 1

Frequent Co-Authors

M. U. Sheth· 2 shared A. J. Armstrong· 1 shared B. Alman· 1 shared B. C. Miller· 1 shared B. C. Thomas· 1 shared D. G. Kirsch· 1 shared D. Sivaraj· 1 shared E. J. Martz· 1 shared

Activity by Year

2022-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCancer Biology

M. U. Sheth

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

A synthetic lethal screen for Snail-induced enzalutamide resistance identifies JAK/STAT signaling as a therapeutic vulnerability in prostate cancer

K. E. Ware, B. C. Thomas, P. Olawuni, M. U. Sheth, N. Hawkey, Y. M, B. C. Miller, K. Vietor, M. K. Jolly, S. Y. Kim, A. J. Armstrong, J. A. Somarelli

The paper identifies JAK/STAT signaling as a therapeutic target for Snail-induced enzalutamide-resistant prostate cancer through synthetic lethal screens and validation in a resistant cell model.

Frontiers in Molecular Biosciences · May 9, 2023Peer-reviewedCancer Biology

Loss of the chromatin remodeler, ATRX, promotes aggressive features of osteosarcoma with increased NF-κB signaling and integrin receptor binding

S. Bartholf DeWitt, S. Hoskinson Plumlee, H. E. Brighton, D. Sivaraj, E. J. Martz, M. Zand, V. Kumar, M. U. Sheth, W. Floyd, J. Spruance, N. Hawkey, S. Varghese, J. Ruan, D. G. Kirsch, J. Somarelli, , W. C. Eward

This study shows that loss of ATRX in osteosarcoma promotes aggressive tumor features through NF-κB signaling and integrin receptor binding, suggesting new therapeutic targets.

bioRxiv · Apr 22, 2022 · PreprintCancer Biology