Author

J. Spruance

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:development & morphogenesis· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

W. C. Eward· 2 shared A. Fahlman· 1 shared A. M. Blawas· 1 shared A. S. Allen· 1 shared B. Alman· 1 shared D. G. Kirsch· 1 shared D. L. Corcoran· 1 shared D. P. Nowacek· 1 shared

Activity by Year

2021-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCancer Biology

W. C. Eward

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2 papers

Recent·Most cited

Loss of the chromatin remodeler, ATRX, promotes aggressive features of osteosarcoma with increased NF-κB signaling and integrin receptor binding

S. Bartholf DeWitt, S. Hoskinson Plumlee, H. E. Brighton, D. Sivaraj, E. J. Martz, M. Zand, V. Kumar, M. U. Sheth, W. Floyd, J. Spruance, N. Hawkey, S. Varghese, J. Ruan, D. G. Kirsch, J. Somarelli, , W. C. Eward

This study shows that loss of ATRX in osteosarcoma promotes aggressive tumor features through NF-κB signaling and integrin receptor binding, suggesting new therapeutic targets.

bioRxiv · Apr 22, 2022 · PreprintCancer Biology

An integrated comparative physiology and molecular approach pinpoints mediators of breath-hold capacity in dolphins

A. M. Blawas, K. E. Ware, E. Schmaltz, L. Zheng, J. Spruance, A. S. Allen, N. West, N. Devos, D. L. Corcoran, D. P. Nowacek, W. C. Eward, A. Fahlman, J. A. Somarelli

This study identifies ALOX5 upregulation during breath-holding in dolphins as a potential molecular mechanism for ischemic tolerance during diving.

bioRxiv · Jan 20, 2021Physiology