E. Jan

Cleavage of 14-3-3ϵ by the enteroviral 3C protease dampens RIG-I mediated antiviral signaling

This study shows that enteroviral 3C protease cleaves 14-3-3ε, disrupting RIG-I signaling and promoting viral infection.

Multiple viral protein genome-linked proteins compensate viral translation in +ssRNA virus infection

The paper investigates how multiple VPg proteins in dicistroviruses compensate for differences in IRES translation efficiency to promote infection.

Targeting Nup358/RanBP2 by a viral protein disrupts stress granule formation

This paper identifies a viral protein that inhibits stress granule formation by targeting Nup358/RanBP2, revealing a mechanism by which viruses modulate cellular stress responses to promote infection.

Eukaryotic translation initiation factor 2A protects pancreatic beta cells during endoplasmic reticulum stress while rescuing translation inhibition.

This study shows EIF2A protects pancreatic beta cells from ER stress by rescuing translation inhibition and reducing apoptosis.

Resurrection of a viral internal ribosome entry site from a 700 year old ancient Northwest Territories cripavirus

The paper resurrects a functional internal ribosome entry site (IRES) from a 700-year-old ancient virus, showing it supports translation and virus infection in a modern context.

The papain-like protease of coronaviruses cleaves ULK1 to disrupt host autophagy

This study identifies SARS-CoV-2 papain-like protease (PLpro) as a novel substrate of ULK1, demonstrating its role in disrupting host autophagy to promote viral replication.

IRES-mediated ribosome repositioning directs translation of a +1 overlapping ORF that enhances viral infection

The paper shows that an IRES from Cricket paralysis virus directs translation of a +1 overlapping ORF, enhancing viral infection through ribosome repositioning.