S. Flibotte

PAN2-PAN3 deadenylase activity is selectively required for mitotic robustness under microtubule stress

This study shows that PAN2-PAN3 deadenylase activity is required for mitotic robustness under microtubule stress in yeast and human cells.

Transcriptomic profiling of the adult reptilian dentition sheds light on the genes regulating indefinite tooth replacement

This study profiles the transcriptome of adult lizard teeth to identify genes regulating indefinite tooth replacement, finding SEMA3A and SFRP2 may be involved in tooth resorption and eruption.

An impedance-based chemiresistor for the real-time detection of gut microbiota-generated short-chain fatty acids

This paper develops an impedance-based sensor for real-time, direct detection of SCFAs in liquid samples without sample preparation, showing its ability to measure SCFAs in mixtures and screen bacterial isolates.

Multiple viral protein genome-linked proteins compensate viral translation in +ssRNA virus infection

The paper investigates how multiple VPg proteins in dicistroviruses compensate for differences in IRES translation efficiency to promote infection.

Effects of hyperinsulinemia on pancreatic cancer development and the immune microenvironment revealed through single-cell transcriptomics

This study uses single-cell transcriptomics to show hyperinsulinemia affects pancreatic cancer development and immune microenvironment by altering immune cell pathways and reducing pre-cancerous lesions.

A new hypothesis for type 1 diabetes risk: The at-risk allele at rs3842753 associates with increased beta cell INS mRNA in a meta-analysis of single cell RNA sequencing data

This study finds that the rs3842753 C allele is associated with higher INS mRNA and ER stress in beta cells, suggesting a link between genetic variation and beta cell dysfunction in type 1 diabetes.

Beta-cell specific Insr deletion promotes insulin hypersecretion and improves glucose tolerance prior to global insulin resistance

This study shows that deleting the insulin receptor in beta-cells improves glucose tolerance in some mice but not others, depending on age and diet.