Author

K. MacDonald

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Cancer Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:cell type annotation· 3 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

A. Civitarese· 1 shared A. McCart Reed· 1 shared C. B. Verchere· 1 shared C. Ledoux· 1 shared C. Moraes· 1 shared C. Xiao· 1 shared D. A. Dionne· 1 shared D. Bessette· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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1 shared paperCancer Biology

A. Civitarese

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

The potential of Senicapoc, a KCNN4 inhibitor, for the prevention and treatment of breast cancer

G. Chenevix-Trench, K. Britt, C. Xiao, M. Miranda, W. Shi, J. Beesley, J. Saunus, A. Civitarese, D. Black, M. Ruppert, M. Perreira, S. Jackson, Z. Teale, D. Carter-Cusack, L. Kalinowski, , F. Al-Ejeh

This study investigates Senicapoc, a KCNN4 inhibitor, and finds it delays mammary tumor development and slows tumor growth in mouse models, suggesting potential for breast cancer prevention and treatment.

bioRxiv · Apr 25, 2023 · PreprintCancer Biology

Eukaryotic translation initiation factor 2A protects pancreatic beta cells during endoplasmic reticulum stress while rescuing translation inhibition.

E. Panzhinskiy, S. Skovso, H. H. Cen, K. Y. Chu, K. MacDonald, G. Soukhatcheva, D. A. Dionne, L. K. Hallmaier-Wacker, J. S. Wildi, S. Marcil, N. Noursadeghi, F. Taghizadeh, C. B. Verchere, E. Jan, J. D. Johnson

This study shows EIF2A protects pancreatic beta cells from ER stress by rescuing translation inhibition and reducing apoptosis.

bioRxiv · Feb 17, 2021 · PreprintPhysiology

Mapping cellular-scale internal stiffness in 3D tissues with smart material hydrogel probes

S. Mok, S. Al Habyan, C. Ledoux, W. Lee, K. MacDonald, L. McCaffrey, C. Moraes

The paper develops smart material microgels to measure cellular-scale stiffness in 3D tissues and identifies high stiffness regions in cancer spheroids and tumors.

bioRxiv · Nov 15, 2019Biophysics

3D Ultrastructure of the Cochlear Outer Hair Cell Lateral Wall Revealed By Electron Tomography

W. Triffo, H. Palsdottir, D. G. Morgan, K. MacDonald, R. M. Raphael, M. Auer

This study uses electron tomography to reveal the 3D ultrastructure of the cochlear outer hair cell lateral wall, showing anisotropic structural rigidity and complex membrane-cytoskeletal connections.

bioRxiv · Jan 29, 2019Biophysics