H. Luo

A novel mechanism of microbial attachment: the flagellar pump of Giardia lamblia

This study identifies a hydrodynamic mechanism of microbial attachment in Giardia lamblia, showing that flagellar-generated fluid flow creates negative pressure sufficient for attachment to various surfaces.

Chemically induced cell plasticity enables the generation of high-fidelity embryo model

This paper develops a chemical-only method to generate high-fidelity embryo models by inducing cell plasticity in stem cells, resulting in embryo-like structures that recapitulate early developmental stages.

A standalone reverse dissimilatory sulfite reductase (rDsr) pathway enables sulfur oxidation under oxygen limitation

This study shows that the reverse dissimilatory sulfite reductase (rDsr) pathway can independently oxidize thiosulfate under low oxygen conditions, supporting its ecological role in marine sediments.

Brain-derived exosomal hemoglobin transfer contributes to neuronal mitochondrial homeostasis under hypoxia

This study identifies exosomal hemoglobin transfer from non-neuronal cells to neurons under hypoxia as a mechanism to maintain mitochondrial homeostasis and protect against neurological injury.

New isolates refine the ecophysiology of the Roseobacter CHAB-I-5 lineage

The paper isolates two new CHAB-I-5 strains, analyzes their genomes, and proposes a new genus and species, highlighting ecological and physiological differences.

Nicotine Ameliorates α-synuclein Pre-formed Fibril-Induced Behavioral Deficits and Pathological Features in Mice

This study shows nicotine reduces α-synuclein pathology and behavioral deficits in mice induced by human α-synuclein pre-formed fibrils.

Meta-transcriptomic analysis of companion animal infectomes reveals their diversity and potential roles in animal and human disease

The paper analyzes meta-transcriptomic data from companion animals to identify microbial communities and assess zoonotic risks.

A neutral process of genome reduction in marine bacterioplankton

The paper investigates genome reduction in marine bacterioplankton, finding that neutral processes like genetic drift, not streamlining selection, drive genome size reduction in the Roseobacter group.

Comparison and Evaluation of Neutralization of Clinically Frequently Used Antimicrobial Agents Using Three Different Culture Media in Simulated Blood Cultures

This study evaluates three blood culture media for antimicrobial neutralization, finding BACT/ALERT media outperformed others in recovery rates, while Thermo media had the lowest performance.

LLPS condensates of Fha initiate the inside-out assembly of the type VI secretion system

This study identifies Fha as the initiator of T6SS assembly in Acidovorax citrulli, showing it forms LLPS condensates that recruit T6SS components, revealing an inside-first assembly model.

Hummingbirds rapidly respond to the removal of vision and control a sequence of rate-commanded maneuvers in milliseconds

This study shows hummingbirds control rapid flight maneuvers using rate-commanded movements and respond to vision loss after a critical time during escape sequences.

Resistance mechanisms of SARS-CoV-2 3CLpro to the non-covalent inhibitor WU-04

This study identifies two double mutations in SARS-CoV-2 3CLpro that confer resistance to the non-covalent inhibitor WU-04 and reveals trade-offs between catalytic activity, thermostability, and drug resistance.

Rhodococcus equi Escapes Macrophage Autophagy: VapA Inhibits ATP6V0d1-Mediated Lysosomal Degradation

This study shows that VapA from Rhodococcus equi inhibits macrophage autophagy by blocking ATP6V0D1, allowing the bacteria to escape lysosomal degradation.

Emergence of Prochlorococcus in the Tonian oceans and the initiation of Neoproterozoic oxygenation

This study shows Prochlorococcus emerged in deep Tonian oceans, enhancing oxygen production and displacing other bacteria, contributing to Neoproterozoic oxygenation.

Multifaceted proteome analysis at solubility, redox, and expression dimensions for target identification

The paper introduces PISA-REX, a high-throughput proteomics method combining redox, expression, and solubility analysis, and demonstrates its application in studying interferon responses in human monocytes and mice.

Hummingbirds use wing inertial effects to improve maneuverability

This study identifies how hummingbirds use wing inertial effects to enhance maneuverability during flight by splitting wingbeat cycles into agility and stability phases.

Dating the bacterial tree of life with ancient symbiosis

This paper estimates the timing of bacterial evolution using ancient symbiosis and eukaryotic fossils, finding the last bacterial common ancestor occurred 4.0-3.5 billion years ago.

ERG activates a stem-like proliferation-differentiation program in prostate epithelial cells with mixed basal-luminal identity

The paper identifies a stem-like proliferative state in prostate epithelial cells driven by ERG activation, which transitions to luminal cells and is associated with specific chromatin states.

Phage administration with repeated intravenous doses leads to faster phage clearance in mammalian hosts

This study evaluates phage clearance and host responses to repeated intravenous phage doses in rats and monkeys, finding faster clearance and immune activation with repeated administration.

Small volume blood-brain barrier opening in macaques with a 1 MHz ultrasound phased array

This paper demonstrates small volume BBB opening in macaques using a 1 MHz ultrasound phased array and characterizes safe pressure ranges and correlation between simulations and measurements.

USP39 promotes hepatocellular carcinogenesis through regulating alternative splicing in cooperation with SRSF6/HNRNPC

This study shows USP39 promotes liver cancer by regulating alternative splicing through interaction with SRSF6/HNRNPC, identifying it as a potential therapeutic target.

Changes of platelet morphology, ultrastructure and function in patients with acute ischemic stroke based on super-resolution microscopy.

This study uses super-resolution microscopy to analyze platelet morphology, ultrastructure, and function in acute ischemic stroke patients, revealing structural and functional changes and demonstrating the utility of the technique for assessing antiplatelet drugs.

Cleavage of 14-3-3ϵ by the enteroviral 3C protease dampens RIG-I mediated antiviral signaling

This study shows that enteroviral 3C protease cleaves 14-3-3ε, disrupting RIG-I signaling and promoting viral infection.

Rapid Speciation Characterized by Incomplete Lineage Sorting in the Globally Distributed Bacterium Sulfitobacter

The paper identifies incomplete lineage sorting in Sulfitobacter, a marine bacterium, showing rapid speciation driven by ancestral polymorphism retention rather than adaptive selection.

FBXO11 deficiency in mice impairs lung development and aggravates cigarette smoke-induced airway fibrosis

This study shows that FBXO11 deficiency in mice leads to impaired lung development and worsens cigarette smoke-induced airway fibrosis by promoting epithelial-mesenchymal transition.

Structure and function of diadenylate cyclase DacM from Mycoplasma ovipneumoniae

This study identifies and characterizes DacM, a diadenylate cyclase in Mycoplasma ovipneumoniae that produces c-di-AMP, and presents its crystal structures to inform drug design.

Lyophilized mRNA-lipid nanoparticle vaccines with long-term stability and high antigenicity against SARS-CoV-2

This paper develops lyophilized mRNA-lipid nanoparticle vaccines that maintain stability at room temperature and show high antigenicity against SARS-CoV-2 variants in preclinical and human trials.

Three-dimensional actuation of hummingbird wings requires diverse effects from the primary flight muscles

This study develops a functional model of hummingbird musculoskeletal system to reveal how primary flight muscles generate three-dimensional wing actuation through diverse effects.

The effector protein CgNLP1 of Colletotrichum gloeosporioides from Hevea brasiliensis disrupts nuclear localization of necrosis-induced transcription factor HbMYB8-like to suppress plant defense signaling

The mitochondrial deubiquitinase USP30 regulates AKT/mTOR signaling

This study shows Parkin promotes AKT degradation during mitophagy, while USP30 protects AKT, influencing cell apoptosis and USP30's broader physiological roles.