T. Singh

Modelling genetic risk of β-cell dysfunction in human induced pluripotent stem cells from patients carrying the MTNR1B risk variant.

This study uses hiPSC and hESC to model the MTNR1B risk variant's effect on β-cell function, finding increased MTNR1B protein and melatonin sensitivity in G-allele carriers.

Prioritized adjustments in posture stabilization and adaptive reaching during neuromuscular fatigue of lower-limb muscles

This study examines how neuromuscular fatigue affects motor adaptation during reaching tasks, finding impaired adaptation and altered muscle activation strategies without affecting postural control.

Anatomy of a mega-radiation: Biogeography and niche evolution in Astragalus

This study investigates the biogeography and niche evolution of Astragalus, finding that chromosome number correlates with diversification, central Asia as the origin, and soil and temperature divergence between hemispheres.

Discovery of a Novel 3site State as the Multi-Substrate Bound State of P450cam

This paper discovers a novel 3site state in P450cam where three substrates bind at distinct sites, including the heme active site, and shows how these binding modes synergistically regulate catalysis.

Notch1 cortical signaling regulates epithelial architecture and cell-cell adhesion

This study shows Notch1 cortical signaling, independent of transcription, regulates epithelial architecture and cell-cell adhesion by stabilizing adherens junctions and cortical actin.

Arp2/3 Complex Activity Enables Nuclear YAP for Naive Pluripotency of Human Embryonic Stem Cells

This study identifies Arp2/3 complex activity as essential for nuclear YAP translocation and naive pluripotency in human embryonic stem cells through actin remodeling and Hippo signaling regulation.

Zinc nano-fertilization enhances wheat productivity and biofortification

This study evaluates zinc oxide nanoparticles (ZnO-NPs) and zinc sulfate (ZnSO4) on wheat growth, yield, and grain zinc concentration, finding ZnO-NPs more effective for biofortification and yield enhancement.

Zika virus-specific IgM elicited during pregnancy exhibits ultrapotent neutralization

This study identifies a potent ZIKV-neutralizing IgM antibody from a pregnant woman and shows its protective efficacy in mice.

Oncogenic c-Myc induces replication stress by increasing cohesins chromatin occupancy

This study identifies a novel mechanism by which c-Myc induces replication stress through increased chromatin-bound cohesins in the G1 phase.

Conduit integrity is compromised during acute lymph node expansion

This study investigates how conduit integrity in lymph nodes changes during acute expansion, finding that while the structure is disrupted, FRC-FRC contacts remain intact and antigen flow becomes leaky.

Conjugated linolenic fatty acids trigger ferroptosis in triple-negative breast cancer

This study identifies conjugated linolenic acids as ferroptosis inducers in triple-negative breast cancer and shows their anti-tumor effects in a xenograft model.