Author

L. Gonzalez

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Biochemistry· 2 Biophysics· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Approach:deep learning· 3 Research Focus:drug response / drug discovery· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2

Frequent Co-Authors

A. Bah· 2 shared A. Barreiro· 2 shared A. Chakraborty· 2 shared A. Dutta· 2 shared A. Fernandez· 2 shared A. Meyerhans· 2 shared C. Boisseau· 2 shared C. de Amat Herbozo· 2 shared

Activity by Year

2020-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersBiochemistry

A. Bah

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Molecular Photoswitches Regulating the Activity of the Human Serotonin Transporter

N. Singer, L. Gonzalez, A. MONARI

The paper uses molecular dynamics simulations to study how cis- and trans-isomers of a photoswitch affect the activity of the human serotonin transporter.

The Journal of Physical Chemistry Letters · Nov 23, 2023Peer-reviewedBiophysics

IFN-γ primes bone marrow neutrophils to acquire regulatory functions in severe viral respiratory infections

F. Creusat, Y. Jouan, L. Gonzalez, E. Barsac, G. Ilango, R. Lemoine, D. Soulard, C. Boisseau, A. Guillon, Q. Lin, C. de Amat Herbozo, V. Sencio, N. Winter, F. Trottein, M. Si-Tahar, , C. Paget

The paper identifies PD-L1+ neutrophils in severe viral respiratory infections, showing they have regulatory functions and are generated in the bone marrow via IFN-γ.

bioRxiv · Nov 23, 2023Immunology

Circulating tumor extracellular vesicles to monitor metastatic prostate cancer genomics and transcriptomic evolution

I. Casanova-Salas, S. Cordoba-Terreros, D. Aguilar, L. Agundez, J. Brandariz, N. Herranz, M. Gonzalez, R. Morales-Barrera, A. Sierra, M. Soriano-Navarro, P. Cresta, S. Simonetti, G. Rodrigues, S. Arce-Gallego, L. Delgado, , J. Mateo

This study shows that circulating tumor extracellular vesicles can be used to monitor genomic and transcriptomic changes in metastatic prostate cancer through liquid biopsy.

bioRxiv · Apr 14, 2023Cancer Biology

Immunogenicity and safety in pigs of PHH-1V, a SARS-CoV-2 RBD fusion heterodimer vaccine candidate

A. Moros, A. Prefaneta, A. Barreiro, E. Perozo, A. Fernandez, M. Canete, L. Gonzalez, C. Garriga, E. Pradenas, S. Marfil, J. Blanco, P. Cebollada-Rica, M. Sistere-Oro, A. Meyerhans, T. Prat Cabanas, , L. Ferrer

This study evaluates the immunogenicity and safety of PHH-1V, a SARS-CoV-2 RBD fusion vaccine in pigs, showing a robust immune response and good safety profile.

bioRxiv · Jan 19, 2023Immunology

Preclinical evaluation of PHH-1V vaccine candidate against SARS-CoV-2 in non-human primates

A. Prenafeta, G. Bech-Sabat, S. Moros, A. Barreiro, A. Fernandez, M. Canete, M. Roca, L. Gonzalez, C. Garriga, J. Confais, M. Toussenot, H. Contamin, A. Pizzorno, M. Rosa-Calatrava, E. Pradenas, , L. Ferrer

This study evaluates the PHH-1V vaccine candidate against SARS-CoV-2 in non-human primates, showing high antibody levels, balanced cellular immunity, and reduced viral load.

bioRxiv · Dec 13, 2022Immunology

FMRP directly interacts with R-loop and shows complex interplay with the DHX9 helicase

A. Chakraborty, A. Dutta, L. G. Dettori, J. Li, L. Gonzalez, X. Xue, H. Hehnly, P. Sung, A. Bah, W. Feng

The paper was withdrawn due to duplicate submission and is not intended for citation.

bioRxiv · Jul 10, 2022Biochemistry

FMRP DIRECTLY INTERACTS WITH R-LOOP AND SHOWS COMPLEX INTERPLAY WITH THE DHX9 HELICASE

A. Chakraborty, A. Dutta, L. G. Dettori, L. Gonzalez, X. Xue, H. Hehnly, P. Sung, A. Bah, W. Feng

This study shows FMRP directly binds R-loops and inhibits DHX9 helicase activity, preventing R-loop accumulation and genome instability in FXS.

bioRxiv · Apr 21, 2021 · PreprintBiochemistry

High dimensional single-cell analysis reveals iNKT cell developmental trajectories and effector fate decision

T. Baranek, K. Lebrigand, C. de Amat Herbozo, L. Gonzalez, G. Bogard, C. Dietrich, V. Magnone, C. Boisseau, Y. Jouan, F. Trottein, M. Si-Tahar, M. Leite-de-Moraes, T. Mallevaey, C. Paget

The paper uses single-cell transcriptomics to uncover developmental trajectories of iNKT cells and identifies FHL2 as a regulator of iNKT1 fate.

bioRxiv · May 12, 2020Immunology