Author

E. R. Miraldi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Microbiology· 2

Signature Assays, Organisms & Methods

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Organism:mouse· 4 Research Focus:cell type annotation· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Research Focus:host-pathogen & immune response· 2 Assay:scRNA-seq· 2

Frequent Co-Authors

A. Garcia-Sastre· 2 shared J. A. Wayman· 2 shared J. S. Y. Ho· 2 shared N. Zhao· 2 shared A. Barski· 1 shared A. C.-Y. Lee· 1 shared A. Godarova· 1 shared A. J. Zhang· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersMicrobiology

A. Garcia-Sastre

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

An atlas of gene regulatory networks for memory CD4+ T cells in youth and old age

J. A. Wayman, A. Thomas, A. T. Bejjani, A. Katko, M. Almanan, A. Godarova, S. Korinfskaya, T. A. Cazares, M. Yukawa, L. C. Kottyan, A. Barski, C. A. Chougnet, D. A. Hildeman, E. R. Miraldi

The paper constructs an atlas of gene regulatory networks for memory CD4+ T cells in young and old mice, revealing age-related changes in transcription factor control and cell-cell communication.

bioRxiv · Mar 7, 2023 · PreprintImmunology

Topoisomerase 1 inhibition therapy protects against SARS-CoV-2-induced inflammation and death in animal models.

J. S. Y. Ho, B. W.-Y. Mok, L. Campisi, T. Jordan, S. Yildiz, S. Parameswaran, J. A. Wayman, N. N. Gaudreault, D. A. Meekins, S. V. Indran, I. Morozov, J. D. Trujillo, Y. S. Fstkchyan, R. Rathnasinghe, Z. Zhu, , Jeya

This study shows that Top1 inhibition with Topotecan reduces SARS-CoV-2-induced inflammation and mortality in animal models.

bioRxiv · Dec 1, 2020 · PreprintMicrobiology

Alternative activation of macrophages is accompanied by chromatin remodeling and short-term dampening of macrophage secondary response

M. S. Tang, E. R. Miraldi, N. M. Girgis, R. A. Bonneau, P. Loke

The paper shows IL-4 activates macrophages with chromatin remodeling and dampens secondary responses, with genetic differences affecting outcomes.

bioRxiv · Mar 8, 2020 · PreprintImmunology

Discovery Of UFO Proteins: Human-Virus Chimeric Proteins Generated During Influenza Virus Infection

Y. Ma, M. Angel, G. Wang, J. S. Y. Ho, N. Zhao, J. Noel, N. Moshkina, J. Gibbs, J. Wei, B. Rosenberg, J. Johnson, M. Chang, Z. Peralta, N. Krogan, C. Benner, , I. Marazzi

The paper identifies host-virus chimeric proteins, called UFOs, generated during influenza virus infection through the translation of viral 5UTRs using host transcripts.

bioRxiv · Apr 8, 2019 · PreprintMicrobiology

Transcriptional regulatory networks that promote and restrict identities and functions of intestinal innate lymphoid cells

M. Pokrovskii, J. A. Hall, D. E. Ochayon, R. Yi, N. S. Chaimowitz, H. Seelamneni, N. Carriero, A. Watters, S. N. Waggoner, D. R. Littman, R. Bonneau, E. R. Miraldi

This study identifies transcriptional regulatory networks in intestinal ILC subsets, revealing key transcription factors and their roles in lineage identity and plasticity.

bioRxiv · Nov 8, 2018Immunology