C. Benner

Activation of the TRIF pathway and downstream targets results in the development of precancerous lesions during infection with Helicobacter.

This study shows that activation of the TRIF pathway and downstream IFN-I signaling promotes H. felis-induced gastric disease progression and is linked to poor survival in gastric cancer.

Breakthrough infections by SARS-CoV-2 variants boost cross-reactive hybrid immune responses in mRNA-vaccinated Golden Syrian Hamsters

This study evaluates hybrid immunity in mRNA-vaccinated hamsters during breakthrough infections, finding enhanced cross-reactive immune responses despite low neutralizing antibody titers.

Derlin Dfm1 Employs a Chaperone Function to Resolve Misfolded Membrane Protein Stress

The paper identifies a chaperone function of Dfm1 in resolving misfolded membrane protein stress in yeast, independent of Cdc48 and distinct from its previously known role in protein dislocation.

Type I IFN promotes pathogenic inflammatory monocyte maturation during H5N1 infection

This study shows that type I IFN promotes the maturation of inflammatory monocytes into pathogenic FasL+MCs during H5N1 infection, contributing to disease severity.

Transcriptional regulatory features associated with Coccidioides immitis phase transition

This study uses csRNA-seq to identify transcriptional changes and regulatory elements during phase transition in Coccidioides immitis, revealing a WOPR homologue involved in pathogenicity.

Mitotic H3K9ac is controlled by phase-specific activity of HDAC2, HDAC3 and SIRT1

The paper identifies HDAC2, HDAC3, and SIRT1 as regulators of H3K9ac during mitosis, showing phase-specific effects on acetylation levels in different mitotic stages.

Functional Landscape of SARS-CoV-2 Cellular Restriction

This study identifies key interferon stimulated genes (ISGs) that restrict SARS-CoV-2 infection by inhibiting viral entry, RNA synthesis, and release.

A Large-scale Drug Repositioning Survey for SARS-CoV-2 Antivirals

This study identifies 30 known drugs that inhibit SARS-CoV-2 replication, with six showing effective concentrations likely to be therapeutic in patients.

Discovery Of UFO Proteins: Human-Virus Chimeric Proteins Generated During Influenza Virus Infection

The paper identifies host-virus chimeric proteins, called UFOs, generated during influenza virus infection through the translation of viral 5UTRs using host transcripts.