J. Wei

The paper uses patient tumor samples to identify lineage- and context-specific mechanisms of innate immune resistance through perturbational single-cell RNA sequencing.

This study identifies NS2B-55 and NS2B-65 variations as responsible for differences in NS2B-NS3 protease activity between JEV genotype I and III using fluorogenic peptide assays.

The paper constructs a spatially-resolved single-cell atlas of the ascidian endostyle, identifying new cell types and evolutionary insights into vertebrate pharyngeal organs.

This study shows that ARAP1 regulates circular dorsal ruffles in Hep3B cells, and its deletion reduces malignant potential, suggesting CDRs contribute to cancer development through nutrient uptake.

This study shows that a dipteran parasite increases host nitric oxide production to regulate 20E synthesis and antibacterial activity, supporting its development.

This paper develops a rotavirus reverse genetics platform enabling exogenous gene insertion and a high-throughput neutralization assay to study immune responses.

This paper develops a PD-1-iRGD conjugate that enhances antitumor efficacy by improving T cell engagement and penetration, and expands a unique population of CD8+ T cells in the tumor microenvironment.

This study shows East Asian herbivorous waterfowl use both seed and green waves during spring migration, with species-specific strategies depending on body size and location.

The paper identifies circular dorsal ruffles as signal platforms for the AKT-mTORC1 pathway in glomerular podocytes, linking them to kidney function and potential therapeutic targets.

The paper shows cpSRP54 and FtsH work together in thylakoid membrane protein quality control during de-etiolation in Arabidopsis, and provides a trackable marker for monitoring their activities.

This paper shows that a chitosan oligosaccharide analog disrupts fungal cell wall organization by targeting PHR transglucosidases, leading to antifungal activity and synergy with existing fungicides.

The paper develops and characterizes monospecific and bispecific monoclonal antibodies that neutralize SARS-CoV-2 and its variants, including B.1.617.2 Delta.

This study identifies 4-vinylanisole as an aggregation pheromone that promotes sexual maturation synchrony in gregarious female locusts through a juvenile hormone/vitellogenin pathway.

This study identifies urine proteome changes in a rat model of simvastatin-induced skeletal muscle injury, highlighting potential biomarkers for SAMS.

This study isolates and characterizes two mesenchymal stem cell lines from a neonatal common hippo, showing their fibroblastoid morphology, normal karyotype, and stemness markers, with distinct differentiation potentials.

This study identifies GRP78 as a positive regulator of HBV enveloped-particle secretion through direct interaction with preS1, suggesting it as a potential therapeutic target.

This study extracts and purifies β-2,7,11-cembratriene-4,6-diol from tobacco leaves and demonstrates its antiviral activity against TMV through in vivo and molecular assays.

The paper identifies a Jurassic fossil as an epiphytic macrolichen, suggesting macrolichen diversity predates the Cenozoic diversification of extant lineages.

The paper investigates off-target mutations caused by prime editors and finds no observable gRNA-independent off-target effects in transfected human cells.

This study establishes and characterizes fibroblast cultures from a female common hippopotamus, confirming their origin and viability for genetic preservation.

This study shows that knocking down PxRdl2 with dsRNA enhances the insecticidal effects of GABAR-targeting compounds against Plutella xylostella.

This study shows that certain aminoglycoside antibiotics inhibit mycobacteriophage infection while others do not, suggesting a mechanism involving the amino sugar group.

This study shows mosquito defensin enhances JEV infection by promoting virus adsorption and down-regulating an antiviral protein.

This study uses human liver organoids to show SARS-CoV-2 infects cholangiocytes, disrupts bile transport, and causes liver damage, suggesting targeting viral effects on the liver could improve COVID-19 treatment.

This paper identifies CD300lf as the primary receptor for murine norovirus in vivo but shows it is not used by human norovirus.

The paper shows that inhibiting the integrin-TGF-β axis enhances NK cell function against glioblastoma stem cells, suggesting it as a therapeutic target.

The paper uses cryo-EM to reveal the post-fusion structure of SARS-CoV-2, showing the S protein in a state with S1 disassociated.

The paper develops individualized ctDNA fingerprint panels to monitor treatment response and recurrence across multiple cancer types using whole-exome sequencing data.

The paper identifies host-virus chimeric proteins, called UFOs, generated during influenza virus infection through the translation of viral 5UTRs using host transcripts.

This study analyzes four genomic biomarkers in 1,000 Chinese cancer patients to assess their distribution and associations with cancer types and mutations.