E. Sala

LSD1 inhibition improves efficacy of adoptive T cell therapy by enhancing CD8+ T cell responsiveness.

This study shows that inhibiting LSD1 enhances CD8+ T cell function in adoptive T cell therapy, leading to improved antitumor immunity and synergistic effects with anti-PDL1 therapy.

A fluorescent reporter model for the visualization and characterization of TDC

This paper introduces a fluorescent reporter model to visualize and characterize TDC, showing their distinct gene signature and increased numbers during viral infection.

The guanine nucleotide exchange factor Rin-like acts as a gatekeeper for T follicular helper cell differentiation via regulating CD28 signaling

This study identifies Rin-like as a negative regulator of Tfh differentiation in mice and humans, showing its role in CD28 signaling and endocytosis.

Controlled administration of aerosolized SARS-CoV-2 to K18-hACE2 transgenic mice uncouples respiratory infection and anosmia from fatal neuroinvasion

This study develops an aerosolized SARS-CoV-2 infection model in K18-hACE2 mice that replicates respiratory symptoms without fatal neuroinvasion, offering a more accurate representation of human COVID-19 pathogenesis.

Immunogenicity and pre-clinical efficacy of an OMV-based SARS-CoV-2 vaccine

This study demonstrates that OMV-based SARS-CoV-2 vaccines induce neutralizing antibodies and protect mice from viral challenge.

COVID-eVax, an electroporated plasmid DNA vaccine candidate encoding the SARS-CoV-2 Receptor Binding Domain, elicits protective immune responses in animal models of COVID-19

This paper evaluates a DNA vaccine candidate, COVID-eVax, which induces strong neutralizing antibodies and T cell responses against SARS-CoV-2 in animal models, showing protective effects against viral challenge.

3D-printed moulds for image-guided surgical biopsies: an open source computational platform

This paper develops an open-source computational platform to create 3D-printed moulds for image-guided surgical biopsies, achieving accurate co-registration of imaging and tissue samples.

Comprehensive characterisation of cell-free tumour DNA in plasma and urine of patients with renal tumours

The paper uses sequencing methods to show that cell-free tumour DNA levels are low in renal cancer but can still be informative with improved detection strategies.

Unraveling Tumor-Immune Heterogeneity in Advanced Ovarian Cancer Uncovers Immunogenic Effect of Chemotherapy

This study analyzes tumor-immune heterogeneity in ovarian cancer before and after chemotherapy, finding that chemotherapy increases cytotoxic immune activation in site-matched samples.