J. Gorman

HIV-1 neutralizing antibodies in SHIV-infected macaques recapitulate structurally divergent modes of human V2 apex recognition with a single D gene

This study isolates and characterizes V2 apex-directed neutralizing antibodies from SHIV-infected macaques, revealing structural and genetic features that enable broad neutralization.

Potent and pan-neutralization of SARS-CoV-2 variants of concern by DARPins

This paper reports the development of two DARPins, FSR16m and FSR22, that potently neutralize SARS-CoV-2 variants, including emerging ones, with efficacy comparable to therapeutic antibodies.

Prefusion-Stabilized Lassa Virus Trimer Identifies Neutralizing Nanobodies and Reveals an Apex-Situated Site of Vulnerability

This paper develops a prefusion-stabilized Lassa virus GPC, identifies a neutralizing nanobody, and reveals a cleavage-dependent site of vulnerability at the trimer apex.

Active vision during prey-capture in wild marmoset monkeys

This study examines prey-capture in wild marmosets to show how vision guides and corrects motor actions during hunting.

Vaccine-elicitation of cross-group neutralizing protective antibodies to influenza A viruses

This study shows that co-immunization with stem immunogens from group 1 and 2 influenza A HAs elicits cross-group neutralizing antibodies and protective immunity in multiple animal models.

Augmenting Neutralization breadth against Diverse HIV-1 by increasing the Ab-Ag interface on V2

This study identifies a lineage of antibodies from infected rhesus macaques that neutralize 54% of HIV-1 strains by expanding the antibody-Env interface around the V2 loop.

Potent SARS-CoV-2 Neutralizing Antibodies Directed Against Spike N-Terminal Domain Target a Single Supersite

This study identifies potent SARS-CoV-2 neutralizing antibodies targeting the N-terminal domain (NTD) and reveals they bind a common supersite on the spike protein.

Real-time conformational dynamics of SARS-CoV-2 spikes on virus particles

This study uses smFRET to observe real-time conformational dynamics of SARS-CoV-2 spikes on virus particles, revealing multiple states and mechanisms of neutralization by antibodies and convalescent plasma.

Recapitulation of HIV-1 Env-Antibody Coevolution in Macaques Leading to Neutralization Breadth

Virus-antibody coevolution in rhesus macaques recapitulates developmental features of human antibodies.

Potent Neutralizing Antibodies Directed to Multiple Epitopes on SARS-CoV-2 Spike

The paper isolates and characterizes 61 SARS-CoV-2-neutralizing monoclonal antibodies from infected patients, identifying potent antibodies targeting multiple epitopes on the spike protein.

Cryo-EM Structures Delineate a pH-Dependent Switch that Mediates Endosomal Positioning of SARS-CoV-2 Spike Receptor-Binding Domains

This paper uses cryo-EM to show how SARS-CoV-2 spike protein undergoes pH-dependent structural changes that affect ACE2 binding and antibody evasion.

Structure-Based Design with Tag-Based Purification and In-Process Biotinylation Enable Streamlined Development of SARS-CoV-2 Spike Molecular Probes

The paper develops biotin-labeled SARS-CoV-2 spike molecular probes using structure-based design and purification methods, achieving high yields and enabling antibody characterization.

Development of genetic tools for the thermophilic filamentous fungus Thermoascus aurantiacus

This study develops genetic tools for Thermoascus aurantiacus, including a transformation system, CRISPR/Cas9 gene editing, and sexual crossing protocol, to enhance enzyme production.

Streptococcus pyogenes M1T1 variants activate caspase-1 and induce an inflammatory neutrophil phenotype

This study shows that M1T1 GAS variants induce caspase-1 activation and an inflammatory neutrophil phenotype, promoting inflammation but not bacterial clearance.

Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1

This study shows that targeting the HIV-1 fusion peptide with specific immunogens induces cross-clade neutralizing antibodies in animals.