P. Jay

Repeated loss of function at HD mating-type genes and of recombination suppression without mating-type locus linkage in anther-smut fungi

The paper shows that HD mating-type genes have lost function in three Microbotryum species, with PR genes controlling mating compatibility, and reports evolutionary strata from recombination suppression.

Tuft cell-derived acetylcholine is an effector of type 2 immunity and directly targets helminth parasites in the gut lumen

The paper shows tuft cells release acetylcholine to directly target helminth parasites in the gut, enhancing type 2 immunity.

The genome sequence of the scarce swallowtail, Iphiclides podalirius

This paper presents a chromosome-level genome assembly for the scarce swallowtail butterfly and reports a negative correlation between chromosome length and heterozygosity at fourfold-degenerate sites.

CDK8 and CDK19 act redundantly to control the CFTR pathway in the intestinal epithelium

The paper shows CDK8 and CDK19 redundantly regulate the CFTR pathway in intestinal epithelium, leading to mucus accumulation and goblet cell secretion when both are deleted.

Supergene formation: evidence for recombination suppression among multiple functional loci within inversions.

The paper investigates supergene formation in Heliconius numata, showing chromosomal inversions suppress recombination among multiple loci controlling wing patterns, supporting the hypothesis that supergenes evolve through recombination suppression and subsequent recruitment of adaptive mutations.

Balancing selection at a wing pattern locus is associated with major shifts in genome-wide patterns of diversity and gene flow in a butterfly

The paper examines how balancing selection at a wing pattern locus in butterflies affects genome-wide diversity and gene flow, finding higher diversity and lower geographic structure in polymorphic populations.

Tempo of degeneration across independently evolved non-recombining regions

The paper quantifies the tempo of degeneration in non-recombining regions by analyzing codon usage and synonymous substitutions in mating-type chromosomes of fungi.

Modeling the stepwise extension of recombination suppression on sex chromosomes and other supergenes through deleterious mutation sheltering

This paper models how recombination suppression on sex chromosomes and supergenes expands stepwise by sheltering recessive deleterious mutations, without requiring sexually antagonistic selection.

Admixture can readily lead to the formation of supergenes

The paper shows that admixture can lead to supergene formation through the evolution of chromosomal inversions with recessive fitness costs.

A semi-automated intestinal organoid screening method demonstrates epigenetic control of epithelial differentiation

This study develops a semi-automated intestinal organoid screening method to identify epigenetic regulators of epithelial differentiation, finding that inhibiting type I PRMTs enhances differentiation and blocks adenoma growth.

Mutation accumulation in chromosomal inversions maintains wing pattern polymorphism in a butterfly

The paper shows chromosomal inversions maintain wing pattern polymorphism in butterflies by accumulating recessive mutations that prevent fixation despite ecological advantages.

Supergene evolution triggered by the introgression of a chromosomal inversion

The paper shows that supergene alleles in Heliconius numata butterflies arise from introgression of a chromosomal inversion, leading to balanced polymorphism and mimicry polymorphism.