The SARS-CoV-2 Spike protein disrupts human cardiac pericytes function through CD147-receptor-mediated signalling: a potential non-infective mechanism of COVID-19 microvascular disease
E. Avolio, M. Carrabba, R. Milligan, M. Kavanagh Williamson, A. P. Beltrami, K. Gupta, K. T. Elvers, M. Gamez, R. Foster, K. Gillespie, F. Hamilton, D. Arnold, I. Berger, M. Caputo, A. D. Davidson, , P. Madeddu
This paper shows that SARS-CoV-2 Spike protein causes cardiac pericyte dysfunction through CD147-mediated signaling, without infecting the cells.
bioRxiv · Dec 21, 2020Cell Biology