F. Hoffmann

Improving Inverse Folding models at Protein Stability Prediction without additional Training or Data

The paper improves protein stability prediction by modifying existing models with a self-derived term, enhancing their performance without additional training or data.

Atlas-Guided Discovery of Transcription Factors for T Cell Programming

The paper identifies transcription factors driving distinct CD8+ T cell states and shows their impact on tumor control and immunotherapy.

A revised perspective on the evolution of troponin I and troponin T in vertebrates

This study reevaluates the evolution of troponin I and T in vertebrates, identifying new gene classes and genomic loci, and challenging the notion that TNNI3's N-terminal extension is unique to mammals.

Whole genome duplications and the diversification of the Globin-X genes of vertebrates

This study investigates the evolution of GbX genes in vertebrates, showing that whole genome duplications have led to diverse GbX paralogs with distinct retention rates and functional implications.

Fitting side-chain NMR relaxation data using molecular simulations

The paper integrates side-chain NMR relaxation data with molecular dynamics simulations to improve the accuracy of protein dynamics models.

Oxygenation properties of hemoglobin and the evolutionary origins of isoform multiplicity in an amphibious air-breathing fish, the blue-spotted mudskipper (Boleophthalmus pectinirostris)

This study examines hemoglobin oxygenation properties and genomic origins of isoform multiplicity in the blue-spotted mudskipper, finding similar oxygen transport traits to hypoxia-tolerant fish despite functional isoform diversity.

The RAF oncogenes of vertebrates are ohnologs that derive from the two rounds of whole-genome duplications early in vertebrate evolution

This study investigates the evolutionary origin of vertebrate RAF genes, finding they arose from two rounds of whole-genome duplications, with B-RAF showing stronger cancer associations.

Relocation of macrophages maintains the barrier function of the urothelium and protects against persistent infection

The paper shows that macrophage relocation into the urothelium, driven by IL-6 and CX3CL1, helps maintain barrier function and prevent recurrent urinary tract infections.