FCHO controls AP2's critical endocytic roles through a PtdIns4,5P2 membrane-dependent switch
N. R. Zaccai, Z. Kadlecova, V. Kane Dickson, K. Korobchevskaya, J. Kamenicky, O. Kovtun, P. K. Umasankar, A. G. Wrobel, J. G. G. Kaufman, S. R. Gray, K. Qu, P. R. Evans, M. Fritzsche, F. Sroubek, S. Höning, , L. M. Traub
The paper shows FCHO primes AP2 for clathrin-coated vesicle incorporation, triggering FCHO release to enable further AP2 activation and recruitment.
bioRxiv · Apr 2, 2022 · PreprintCell Biology