S. Acharya

CELL CYCLE STATE PREDICTION USING GRAPH NEURAL NETWORKS

The paper predicts mitosis stages using a CNN followed by a GNN, incorporating timestamps as a graph to model internal interactions, achieving performance comparable to state-of-the-art methods.

WASP facilitates tumor mechanosensitivity in T lymphocytes

This study identifies WASP as a key mediator of mechanosensitivity in CTLs, linking mechanical cues from target cells to TCR signaling and immune response.

Reliable, standardized measurements for cell mechanical properties

The paper develops a standardized protocol for measuring mechanical properties of cancer cells using AFM, achieving consistent results across multiple laboratories.

Decoding Root Biogeography: Building Reduced Complexity Functional Rhizosphere Microbial Consortia

This study develops reduced complexity rhizosphere microbial consortia by enriching root-associated microbes from Brachypodium using carbon substrates, revealing their stability and functional roles in plant growth promotion.

Anti-citrullinated protein antibodies with diverse specificities ameliorate collagen antibody-induced arthritis in a time-dependent manner

The study functionally characterizes ACPAs from RA patients and shows they reduce arthritis severity in a mouse model, with effects dependent on timing of treatment.

Single-cell Transcriptomics Reveal Different Maturation Stages and Sublineages Commitment of Human Thymic Invariant Natural Killer T cells

This study uses single-cell RNA sequencing to identify maturation stages and sublineage commitment in human thymic iNKT cells, revealing two distinct clusters with immature and mature profiles.

The Systematic Optimization of Square Wave Electroporation for Six Commonly Used Human Cell Lines

The paper optimizes square wave electroporation parameters for six human cell lines, finding voltage, DNA concentration, and energy density affect transfection efficiency and viability.

A human stem cell resource to decipher the biochemical and cellular basis of neurodevelopmental defects in Lowe Syndrome

This study generates human stem cell lines from Lowe Syndrome patients to investigate the cellular and biochemical mechanisms of brain development defects caused by OCRL1 mutations.

Generation of glucocorticoid resistant SARS-CoV-2 T-cells for adoptive cell therapy

The paper expands SARS-CoV-2 T-cells from COVID-19 donors using IL-2/4/7 cytokines, achieving >1000-fold expansion with preserved function, and inactivates the glucocorticoid receptor to create glucocorticoid-resistant T-cells for adoptive therapy.

Location, location, location: Feeding site affects aphid performance by altering access and quality of nutrients

This study shows that aphid performance on soybean plants depends on feeding location, with stems providing better nutrient quality and accessibility, leading to higher populations and faster development.

Inhibition of the av integrin-TGF-b axis improves natural killer cell function against glioblastoma stem cells

The paper shows that inhibiting the integrin-TGF-β axis enhances NK cell function against glioblastoma stem cells, suggesting it as a therapeutic target.