J. Rao

Mapping kinase domain resistance mechanisms for the MET receptor tyrosine kinase via deep mutational scanning

The paper uses deep mutational scanning to analyze MET kinase domain mutations and their resistance to 11 inhibitors, identifying resistance and sensitizing mutations and improving prediction with a protein language model.

AlphaFold3, a secret sauce for predicting mutational effects on protein-protein interactions

This paper benchmarks AlphaFold3 against SKEMPI to assess its ability to predict mutational effects on protein-protein interactions and compares it with force field and deep learning methods.

Preclinical evaluation of RQ3013, a broad-spectrum mRNA vaccine against SARS-CoV-2 variants

This paper evaluates RQ3013, an mRNA vaccine against SARS-CoV-2 variants, showing robust immune responses and protection in animal models.

Artificial intelligence-driven morphology-based enrichment of malignant cells from body fluid

This study uses deep learning and microfluidic sorting to enrich malignant cells from body fluids, improving detection of tumor fractions and mutations.

Highly Excretable Gold Supraclusters for Translatable In Vivo Raman Imaging of Tumors

This paper develops excretable gold supraclusters for in vivo Raman imaging of tumors, showing high excretion rates and effective tumor detection in mice.

TANKBind: Trigonometry-Aware Neural NetworKs for Drug-Protein Binding Structure Prediction

TANKBind improves drug-protein binding structure prediction by incorporating trigonometry constraints and functional block segmentation, achieving better performance than existing methods.

STK25 inhibits PKA signaling by phosphorylating PRKAR1A

This study identifies STK25 as a kinase that phosphorylates PRKAR1A, inhibiting PKA signaling and reducing myocardial contractility in response to beta adrenergic stimulation.

Multi-parameter optical imaging of immune cell activity in chimeric antigen receptor T-cell and checkpoint blockade therapies

The paper develops a small molecule for imaging immune cell activity in cancer immunotherapies and demonstrates its utility in predicting treatment outcomes.

Single-dose AAV-based vaccine induces a high level of neutralizing antibodies against SARS-CoV-2 in rhesus macaques

This study shows a single-dose AAV-based vaccine induces long-lasting neutralizing antibodies against multiple SARS-CoV-2 variants in rhesus macaques.

Analysis of viral RNA-host protein interactomes enables rapid antiviral drug discovery

The paper identifies antiviral drugs by analyzing RNA-host protein interactomes of SARS-CoV-2, EBOV, and ZIKV.

Prednisolone rescues Duchenne Muscular Dystrophy phenotypes in human pluripotent stem cells-derived skeletal muscle in vitro

This study shows prednisolone rescues DMD phenotypes in iPSC-derived muscle cells, suggesting direct myofiber effects rather than just anti-inflammatory benefits.

Leptin deficient rats develop nonalcoholic steatohepatitis with unique disease progression

This study characterizes LepΔI14/ΔI14 rats as a NASH model through long-term transcriptomic analysis, revealing unique disease progression and gene expression patterns.