H. Lecoeur

This study shows that inhibiting LSD1 in macrophages reduces Leishmania parasite load and reverses infection-induced transcriptomic changes.

This study shows Leishmania amazonensis suppresses macrophage-regulated cell death pathways to promote chronic infection in vitro and in vivo.

This study identifies IGF2BP2 as an m6A reader that stabilizes glycolytic transcripts in Leishmania-infected macrophages, promoting HIF-1-independent glycolysis and immune-metabolic reprogramming.

This study shows that Leishmania-infected macrophages undergo pyroptosis, exposing amastigotes to the extracellular environment, which may aid parasite spread.

This study shows Leishmania amazonensis modulates macrophage epigenetics to suppress NF-κB and NLRP3 inflammasome activation, aiding parasite survival.