Identification and Structural Characterization of a mutant KRAS-G12V specific TCR restricted by HLA-A3
M. J. W. Sim, K.-i. Hanada, Z. S. Stotz, Z. Yu, J. Lu, P. Brennan, M. Quastel, G. Gillespie, E. O. Long, J. C. Yang, P. D. Sun
The paper identifies a TCR specific to KRAS-G12V neoantigen and characterizes its structural interaction with HLA-A3, revealing challenges in targeting this mutation.
bioRxiv · Feb 1, 2024Immunology