Author

A. J. McMichael

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:human· 5 Research Focus:host-pathogen & immune response· 3 Assay:proteomics· 3 Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 1 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1

Frequent Co-Authors

P. Borrow· 4 shared G. M. Gillespie· 3 shared S. Brackenridge· 3 shared E. Brenna· 2 shared L. C. Walters· 2 shared A. N. Davydov· 1 shared B. D. Huisman· 1 shared B. F. Haynes· 1 shared

Activity by Year

2019-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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4 shared papersImmunology

P. Borrow

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

An unbiased characterization of the HLA-E and CD94/NKG2x peptide repertoire reveals peptide ligands that skew NK cell activation

B. D. Huisman, N. Guan, T. Ruckert, L. Garner, N. K. Singh, A. J. McMichael, G. M. Gillespie, C. Romagnani, M. E. Birnbaum

The paper identifies 500 HLA-E-bound peptides that bind CD94/NKG2A or CD94/NKG2C, revealing ligands that modulate NK cell activation.

bioRxiv · Aug 3, 2022Immunology

Mapping the epitopes of the Human Leukocyte Antigen E antibodies 3D12 and 4D12

S. Brackenridge, P. Borrow, A. J. McMichael

This study maps the epitopes of antibodies 3D12 and 4D12 that bind to HLA-E, revealing distinct binding regions on the alpha 3 and alpha 2 domains.

bioRxiv · May 27, 2022Immunology

Mouse and Human Antibodies that Bind HLA-E-Leader Peptide Complexes and Enhance NK Cell Cytotoxicity

D. Li, S. Brackenridge, L. C. Walters, O. Swanson, K. Harlos, D. Rozbesky, D. W. Cain, K. Wiehe, R. M. Scearce, M. Barr, Z. Mu, R. Parks, M. Quastel, R. J. Edwards, Y. Wang, , B. F. Haynes

The paper isolates antibodies that bind HLA-E-Leader peptide complexes and enhance NK cell cytotoxicity in both mice and humans.

bioRxiv · Dec 3, 2020Immunology

HLA-E restricted, HIV-1 suppressing, Gag specific CD8+ T cells offer universal vaccine opportunities

H. Yang, M. Rei, S. Brackenridge, E. Brenna, H. Sun, s. abdulhaqq, M. K. Liu, W. Ma, P. Kurupati, x. Xu, V. Cerundolo, E. Jenkins, S. J. Davis, J. B. Sacha, K. Frueh, , A. J. McMichael

The paper demonstrates that HLA-E restricted, HIV-1 specific CD8+ T cells can suppress HIV-1 replication in vitro, suggesting potential for a universal vaccine.

bioRxiv · Dec 1, 2020 · PreprintImmunology

Detailed and atypical HLA-E peptide binding motifs revealed by a novel peptide exchange binding assay

L. C. Walters, A. J. McMichael, G. M. Gillespie

The paper develops a novel peptide exchange ELISA assay to quantify HLA-E peptide binding and identifies both canonical and non-canonical peptides that bind HLA-E.

bioRxiv · May 5, 2020Immunology

CD4+ T follicular helper (Tfh) cells in human tonsil and blood are clonally convergent, but divergent from non-Tfh CD4+ cells

E. Brenna, A. N. Davydov, K. Ladell, J. E. McLaren, P. Bonaiuti, M. Metsger, S. C. Gilbert, T. Lambe, D. A. Price, S. L. Campion, D. M. Chudakov, P. Borrow, A. J. McMichael

The paper examines clonal relationships between Tfh cells in blood and tonsil, finding clonal convergence between peripheral and tonsillar Tfh cells but divergence from non-Tfh CD4+ cells.

bioRxiv · Aug 22, 2019Immunology