E. Jenkins

Proximity proteomics reveals UCH-L1 as an NLRP3 interactor that modulates IL-1β production in human macrophages and microglia

The paper identifies UCH-L1 as an NLRP3 interactor that modulates IL-1β production in human macrophages and microglia through proximity proteomics and functional assays.

The kinase occupancy of T-cell coreceptors reconsidered

The paper re-evaluates kinase occupancy of T-cell coreceptors CD4 and CD8β, finding CD4-Lck interaction is stoichiometric while CD8β-Lck is substantial, with structural differences influencing binding.

Solution structure and synaptic analyses reveal determinants of bispecific T cell engager potency

The paper evaluates TcE formats to determine how contact distance and flexibility affect their potency in forming immunological synapses.

Different individual-level responses of great black-backed gulls (Larus marinus) to shifting local prey availability

The paper tracks individual gull responses to prey availability shifts, finding diverse foraging strategies that are not detectable at the group level.

New Records of California Serogroup Virus in Aedes Mosquitoes and First Detection in Simulioidae Flies from Northern Canada and Alaska

The paper detects California serogroup virus RNA in Aedes mosquitoes and Simulioidae flies in Northern Canada and Alaska, highlighting the potential of biting insects for tracking arbovirus emergence.

Aggregation and immobilisation of membrane proteins interplay with local lipid order in the plasma membrane of T cells

The paper investigates how membrane protein aggregation and immobilization affect lipid order in T cells, revealing lipid-mediated recruitment of signaling proteins like Lck.

HLA-E restricted, HIV-1 suppressing, Gag specific CD8+ T cells offer universal vaccine opportunities

The paper demonstrates that HLA-E restricted, HIV-1 specific CD8+ T cells can suppress HIV-1 replication in vitro, suggesting potential for a universal vaccine.

Robust T-cell signaling triggered on soft polydimethylsiloxane-supported lipid-bilayers

This study investigates T-cell signaling on soft lipid bilayers, finding early calcium signaling is not mechanosensitive but phosphatase exclusion occurs on soft substrates.

Reconstitution of immune cell interactions in free-standing membranes

The paper presents an in vitro system using synthetic vesicles to study spatiotemporal aspects of immune synapse formation and signaling molecule distribution in T cells.