Author

H. Bennett

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 6 Microbiology· 2 Bioengineering· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 10 Research Focus:host-pathogen & immune response· 8 Research Focus:cell type annotation· 3 Organism:human· 3 Organism:mouse· 3 Assay:proteomics· 3 Research Focus:drug response / drug discovery· 2 Organism:non-human primate· 2

Frequent Co-Authors

A. Carfi· 5 shared B. S. Graham· 4 shared A. Choi· 3 shared D. K. Edwards· 3 shared K. Wu· 3 shared M. Koch· 3 shared T. Colpitts· 3 shared C. Hoyle· 2 shared

Activity by Year

2017-2023 · peak 6/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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5 shared papersImmunology

A. Carfi

Mutual co-authors in cluster

Author profile →

10 papers

Recent·Most cited

Proximity labelling and evolutionary evidence reveal insights into IL-1α nuclear networks and function

R. Wellens, V. S. Tapia, H. Bennett, A. Adamson, J. Rivers-Auty, J. P. Green, G. Lopez-Castejon, D. Brough, C. Hoyle

The paper investigates the nuclear role of pro-IL-1 and evolutionary changes in its NLS and HAT-binding domains using proximity labelling and mutation analysis.

bioRxiv · Jun 26, 2023Immunology

A monkeypox mRNA-lipid nanoparticle vaccine targeting virus binding, entry, and transmission drives protection against lethal orthopoxviral challenge

A. W. Freyn, C. Atyeo, P. L. Earl, J. L. Americo, G.-Y. Chuang, H. Natarajan, T. R. Frey, J. Gall, J. I. Moliva, R. Hunegnaw, G. Asthagiri Arunkumar, C. Ogega, A. Nasir, H. Bennett, J. Johnson, , B. Moss

This paper develops an mRNA-lipid nanoparticle vaccine targeting four conserved MPXV surface proteins, showing superior protection against VACV compared to MVA.

bioRxiv · Dec 17, 2022 · PreprintImmunology

An optimized messenger RNA vaccine candidate protects non-human primates from Zika virus infection

B. A. Bollman, N. Nunna, K. Bahl, C. J. Hsiao, H. Bennett, S. Butler, B. Foreman, K. E. Burgomaster, M. Aleshnick, W.-P. Kong, B. E. Fisher, T. J. Ruckward, K. M. Morabito, B. S. Graham, K. A. Dowd, , A. Carfi

This study compares two ZIKV mRNA vaccines, showing that mRNA-1893 provides complete protection at a lower dose than mRNA-1325 in non-human primates.

bioRxiv · Oct 11, 2022 · PreprintImmunology

NLRP3 activation in response to disrupted endocytic traffic

B. Lee, C. Hoyle, J. Green, R. Wellens, F. Martin-Sanchez, D. Williams, P. Seoane, H. Bennett, A. D. Adamson, G. Lopez-Castejon, M. Lowe, D. Brough

This study shows NLRP3 detects disrupted endosome trafficking, leading to inflammasome activation and cytokine release in macrophages.

bioRxiv · Sep 15, 2021Immunology

Tensin3 interaction with talin drives formationof fibronectin-associated fibrillar adhesions

P. Atherton, R. Konstantinou, S. P. Neo, E. Wang, E. Balloi, M. Ptushkina, H. Bennett, K. Clark, J. Gunaratne, D. Critchley, I. Barsukov, E. Manser, C. Ballestrem

This study identifies tensin3's interaction with talin as essential for fibronectin fibrillogenesis and integrin-associated fibrillar adhesions.

bioRxiv · Jul 16, 2021Cell Biology

Serum Neutralizing Activity of mRNA-1273 against SARS-CoV-2 Variants

A. Choi, M. Koch, K. Wu, G. Dixon, J. Oestreicher, H. Legault, G. B. E. Stewart-Jones, T. Colpitts, R. Pajon, H. Bennett, A. Carfi, D. K. Edwards

This study evaluates the neutralizing activity of mRNA-1273 vaccine-induced sera against SARS-CoV-2 variants, finding reduced but still effective neutralization against several variants compared to the wild-type virus.

bioRxiv · Jun 28, 2021Microbiology

Durability of mRNA-1273-induced antibodies against SARS-CoV-2 variants

A. Pegu, S. E. O'Connell, S. D. Schmidt, S. O'Dell, C. A. Talana, L. Lai, J. Albert, E. Anderson, H. Bennett, K. Corbett, B. Flach, L. Jackson, B. Leav, J. E. Ledgerwood, C. J. Luke, , N. A. Doria-Rose

This study assesses the durability of mRNA-1273-induced antibodies against SARS-CoV-2 variants over seven months, finding persistent but reduced binding and functional responses.

bioRxiv · May 13, 2021 · PreprintImmunology

Variant SARS-CoV-2 mRNA vaccines confer broad neutralization as primary or booster series in mice

K. Wu, A. Choi, M. Koch, S. Elbashir, L. Ma, D. Lee, A. Woods, C. Henry, C. Palandjian, A. Hill, H. Jani, J. Quinones, N. Nunna, S. O'Connell, A. B. McDermott, , D. K. Edwards

This study evaluates updated SARS-CoV-2 mRNA vaccines in mice, showing that mRNA-1273.351 boosts neutralization against B.1.351 and mRNA-1273.211 provides broad cross-variant protection.

bioRxiv · Apr 13, 2021Microbiology

mRNA-1273 vaccine induces neutralizing antibodies against spike mutants from global SARS-CoV-2 variants

K. Wu, A. P. Werner, J. I. Moliva, M. Koch, A. Choi, G. B. E. Stewart-Jones, H. Bennett, S. Boyoglu-Barnum, W. Shi, B. S. Graham, A. Carfi, K. S. Corbett, R. A. Seder, D. K. Edwards

This study evaluates the neutralizing antibody response of mRNA-1273 vaccine against SARS-CoV-2 variants B.1.1.7 and B.1.351 using pseudovirus neutralization assays.

bioRxiv · Jan 25, 2021 · PreprintImmunology

Light-Activated Cell Identification and Sorting (LACIS): A New Method to Identify and Select Edited Clones on a Microfluidic Device

A. Mocciaro, T. Roth, H. Bennett, M. Soumillon, A. Shah, J. Hiatt, K. Chapman, A. Marson, G. Lavieu

The paper introduces LACIS, a microfluidic method for identifying and sorting edited clones using Opto-Electronic Positioning, enabling rapid and efficient clonal selection after CRISPR-Cas9 editing.

bioRxiv · Oct 17, 2017Bioengineering