T. Abe

The cadmium-hypertolerant fern, Athyrium yokoscense, exhibits two cadmium stress mitigation strategies in the roots and the aerial parts

This study identifies two Cd stress mitigation strategies in Athyrium yokoscense: Cd-O compound formation in root cell walls and Cd-S compound formation via thiol compounds in root stele.

Spatiotemporal EP4-fibulin-1 expression is associated with vascular intimal hyperplasia

This study identifies EP4 and fibulin-1 as key regulators of vascular intimal hyperplasia through VSMC proliferation, suggesting EP4 antagonists or fibulin-1 downregulation as potential therapeutic strategies.

Insectivorous birds and bats outperform ants in the top-down regulation of arthropods across strata of a Japanese temperate forest

This study compares the top-down control effects of birds, bats, and ants on arthropod communities and plant damage across forest strata in a Japanese temperate forest.

Testing immediate dosage compensation by irradiation of heavy-ion beams to Drosophila miranda

This study tests if immediate dosage compensation occurs in Drosophila miranda by inducing neo-Y deletions and analyzing gene expression in F1 males.

Collective gradient sensing by dilute swimming bacteria without clustering

This study shows that dilute swimming bacteria enhance taxis through collective migration without clustering, by suppressing orientation fluctuations and preventing population dispersion.

PCNA recruits cohesin loader Scc2/NIPBL to ensure sister chromatid cohesion

This study shows PCNA recruits the cohesin loader Scc2/NIPBL to establish sister chromatid cohesion during DNA replication in yeast and vertebrates.

Pacsin 2-dependent N-cadherin internalization regulates the migration behaviour of malignant cancer cells

This study shows that pacsin 2 regulates N-cadherin internalization, affecting collective migration of bladder cancer cells.

Increased mitochondrial Ca2+ contributes to health decline with age and Duchene muscular dystrophy in C. elegans.

This study shows that reducing mitochondrial calcium influx in C. elegans improves age-related and muscular dystrophy muscle decline by mitigating mitochondrial dysfunction.

Clonal spreading of tumor-infiltrating T cells underlies the robust antitumor immune responses

This study shows that polyclonal expansion of tumor-reactive T cells, not oligoclonal expansion, correlates with antitumor effects in response to anti-PD-L1 and anti-CD4 treatments.

Dynamics of peripheral blood flow across sleep stages

This study compares pulse rate variability (PRV) and heart rate variability (HRV) across sleep stages using peripheral blood flow measurements, finding PRV provides similar information to HRV and may offer additional insights.

Small Vessel Diseases: 3D Characteristics of the Vasculature and White Matter

This study examines 2D and 3D vascular and white matter changes in CADASIL, HTRA1-AD, and sSVD using light-sheet fluorescence microscopy, revealing distinct patterns of degeneration.

Imaging-based evaluation of pathogenicity by novel DNM2 variants associated with centronuclear myopathy

The paper evaluates the pathogenicity of novel DNM2 variants associated with centronuclear myopathy using an in cellulo imaging assay of T-tubule-like structures.

Unsupervised explainable AI for simultaneous molecular evolutionary study of forty thousand SARS-CoV-2 genomes

The paper applies an explainable AI method to analyze 40,000 SARS-CoV-2 genomes, revealing clade clustering based on oligonucleotide composition without prior knowledge.

Genome sequencing of ion-beam-induced mutants facilitates the detection of candidate genes responsible for phenotypes of mutants in rice

The paper uses whole-exome sequencing to identify mutations in ion-beam-induced rice mutants, finding high-impact mutations linked to mutant phenotypes.

An asexual flower of Silene latifolia and Microbotryum lychnidis-dioicae promoting its sexual-organ development

The paper investigates how infection by Microbotryum lychnidis-dioicae affects sexual-organ development in an asexual mutant of Silene latifolia, finding that stamen suppression is released but gynoecium suppression is not.

Thick perirenal fat predicts the growth pattern of renal cell carcinoma

This study finds that thick perirenal fat is associated with outward tumor protrusion in renal cell carcinoma.

CDK1 dependent phosphorylation of hTERT contributes to cancer progression

The paper shows CDK1 phosphorylates hTERT at threonine 249, which is required for RdRP activity and promotes cancer progression independently of telomerase.

Dynamic clustering of dynamin-amphiphysin rings regulates membrane constriction and fission coupled with GTP hydrolysis

This study uses EM and HS-AFM to show dynamin-amphiphysin rings cluster during GTP hydrolysis, driving membrane constriction and fission through a novel clusterase mechanism.