Author

H. L. Chan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Assay:proteomics· 1

Frequent Co-Authors

L. Morey· 2 shared C. Banuelos· 1 shared C. Premer· 1 shared D. Bilbao· 1 shared D. Dominguez· 1 shared D. Salyakina· 1 shared E. Mesri· 1 shared J. Brabson· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCancer Biology

L. Morey

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2 papers

Recent·Most cited

Methylation of histone H3 lysine 36 is a barrier for therapeutic interventions of head and neck squamous cell carcinoma.

L. Caeiro, Y. Nakata, R. L. Borges, L. Garcia-Martinez, C. Banuelos, S. Stransky, H. L. Chan, J. Brabson, D. Dominguez, Y. Zhang, P. W. Lewis, S. A. Benitah, L. Cimmino, D. Bilbao, S. Sidoli, , L. Morey

This study shows that H3K36M mutations in HNSCC create a therapeutic window by altering H3K27me3 levels, making tumors sensitive to PARP1/2 inhibitors or their combination with H3K27me3-upregulating agents.

bioRxiv · Nov 6, 2023Cancer Biology

PDGFRA Defines the Mesenchymal Stem Cell Kaposi’s Sarcoma Progenitors by Enabling KSHV Oncogenesis in an Angiogenic Environment

J. Naipauer, S. Rosario, S. Gupta, C. Premer, O. Mendez, M. Schlesinger, V. Ponzinibbio, V. Jain, L. Gay, R. Renne, H. L. Chan, L. Morey, D. Salyakina, M. Abba, S. Williams, , E. Mesri

The paper identifies PDGFRA+ bone marrow-derived mesenchymal stem cells as Kaposi’s sarcoma progenitors and shows pro-angiogenic conditions enable KSHV oncogenesis through epigenetic de-repression.

bioRxiv · Oct 2, 2019Cancer Biology