Author

H. L. Grimes

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Immunology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Approach:microscopy & imaging analysis· 2 Organism:mouse· 2 Research Focus:spatial domain detection· 2 Assay:spatial transcriptomics· 2 Assay:bulk RNA-seq· 1 Approach:deep learning· 1 Research Focus:differential expression· 1

Frequent Co-Authors

A. Slaughter· 2 shared B. Weinhaus· 2 shared C. B. Johnson· 2 shared D. Lucas· 2 shared J. Zhang· 2 shared Q. Wu· 2 shared A. Dalessandro· 1 shared A. Fromowitz· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersPhysiology

A. Slaughter

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Broad de-regulated U2AF1 splicing is prognostic and augments leukemic transformation via protein arginine methyltransferase activation

M. Venkatasubramanian, L. Schwartz, N. Ramachandra, J. Bennett, K. R. Subramanian, S. Gordon-Mitchell, A. Fromowitz, K. Pradhan, D. Shechter, S. Sahu, D. Heiser, P. Scherle, X. Chen, C. Chetal, A. Kulkarni, , N. G. Salomonis

The paper identifies a splicing mechanism in AML independent of mutations, showing it drives poor prognosis and can be targeted with PRMT5 inhibition.

bioRxiv · Feb 4, 2024Cancer Biology

Resilient anatomy and local microplasticity of naïve and stress hematopoiesis

Q. Wu, J. Zhang, C. B. Johnson, A. Slaughter, B. Weinhaus, M. McKnight, B. E. Sherman, T.-y. Shao, B. Song, M. D. Filippi, H. L. Grimes, S. S. Way, J. M. Kofron, D. Lucas

This study identifies durable microanatomical production lines in hematopoiesis that maintain blood cell production during stress and aging.

bioRxiv · May 23, 2022 · PreprintPhysiology

Three-dimensional mapping identifies distinct vascular niches for myelopoiesis

J. Zhang, Q. Wu, C. B. Johnson, A. Olsson, A. Slaughter, M. May, B. Weinhaus, A. Dalessandro, J. D. Engel, J. X. Jiang, M. Kofron, L. F. Huang, N. Salomonis, H. L. Grimes, D. Lucas

This paper maps 3D vascular niches for myeloid differentiation in bone marrow, revealing distinct spatial organization of granulocyte and monocyte/dendritic cell progenitors.

bioRxiv · Apr 2, 2020 · PreprintImmunology