The Functional Landscape of SARS-CoV-2 3CL Protease
S. Iketani, S. J. Hong, J. Sheng…·A. Chavez
This study maps the functional landscape of SARS-CoV-2 3CL protease by profiling all single mutants and identifies resistance mutations to nirmatrelvir.
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3 papers
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S. Iketani, S. J. Hong, J. Sheng…·A. Chavez
This study maps the functional landscape of SARS-CoV-2 3CL protease by profiling all single mutants and identifies resistance mutations to nirmatrelvir.
S. Posada-Cespedes, G. Van Zyl, H. Montazeri…·N. Beerenwinkel
This paper compares mutational pathways to lopinavir resistance in HIV-1 subtypes B and C using a probabilistic model, finding distinct initial mutations and diverse evolutionary pathways.
G. Bianco, M. Coto Llerena, J. Gallon…·S. Piscuoglio
This study identifies GATA3 and MDM2 as synthetic lethal in ER-positive breast cancers, showing MDM2 inhibition can target GATA3-deficient tumors via the PI3K/Akt/mTOR pathway.