Author

B. Culbertson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Microbiology· 2 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

H. Goodarzi· 3 shared K. Garcia· 3 shared A. Chavez· 2 shared A. Navickas· 2 shared D. D. Ho· 2 shared D. Markett· 2 shared H. Asgharian· 2 shared J. Yu· 2 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersCancer Biology

H. Goodarzi

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Inhibition of muscarinic receptor signaling protects human enteric inhibitory neurons against platin chemotherapy toxicity

M. N. Richter, S. Farahvashi, R. M. Samuel, H. Majd, A. K. Chemel, J. T. Ramirez, A. Majd, M. D. Scantlen, N. Elder, A. Cesiulis, K. Garcia, T. Joshi, M. G. Keefe, B. Samiakalantari, E. M. Turkalj, , F. Fattahi

This study identifies muscarinic receptor signaling as a key driver of platin-induced enteric neuropathy and shows that its inhibition protects neurons from toxicity.

bioRxiv · Mar 8, 2023 · PreprintPharmacology & Toxicology

Multiple pathways for SARS-CoV-2 resistance to nirmatrelvir

S. Iketani, H. Mohri, B. Culbertson, S. J. Hong, Y. Duan, M. I. Luck, M. K. Annavajhala, Y. Guo, Z. Sheng, A.-C. Uhlemann, S. P. Goff, Y. Sabo, H. Yang, A. Chavez, D. D. Ho

This study identifies multiple mutational pathways leading to nirmatrelvir resistance in SARS-CoV-2 through in vitro experiments and structural analysis.

bioRxiv · Aug 7, 2022Microbiology

The Functional Landscape of SARS-CoV-2 3CL Protease

S. Iketani, S. J. Hong, J. Sheng, F. Bahari, B. Culbertson, F. F. Atanaki, A. K. Aditham, A. F. Kratz, M. I. Luck, R. Tian, S. P. Goff, H. Montazeri, Y. Sabo, D. D. Ho, A. Chavez

This study maps the functional landscape of SARS-CoV-2 3CL protease by profiling all single mutants and identifies resistance mutations to nirmatrelvir.

bioRxiv · Jun 23, 2022 · PreprintMicrobiology

A sense-antisense RNA interaction promotes breast cancer metastasis via regulation of NQO1 expression

B. Culbertson, K. Garcia, D. Markett, H. Asgharian, L. Chen, L. Fish, A. Navickas, J. Yu, B. Woo, S. Nanda, J. Rabinowitz, H. Goodarzi

The paper identifies an antisense RNA, NQO1-AS, that promotes breast cancer metastasis by stabilizing NQO1 mRNA, enhancing oxidative stress tolerance and enabling lung colonization.

bioRxiv · Oct 8, 2021Cancer Biology

An mRNA processing pathway suppresses metastasis by governing translational control from the nucleus

A. Navickas, H. Asgharian, J. Winkler, L. Fish, K. Garcia, D. Markett, M. Dodel, B. Culbertson, S. Miglani, T. Joshi, P. Nguyen, S. Zhang, N. Stevers, H.-W. Hwang, F. Mardakheh, , H. Goodarzi

The paper identifies HNRNPC and PABPC4 as regulators of alternative polyadenylation that suppress breast cancer metastasis by controlling mRNA translation.

bioRxiv · Oct 4, 2021Cancer Biology