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Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
10 papers
Recent·Most cited
This paper introduces an experimental approach to assess whether epigenetic inheritance contributes to rapid adaptation through stochastic or deterministic routes in plants.
bioRxiv · Oct 12, 2023 · PreprintEvolutionary Biology
Y. Wang, P. Duchen, A. Chavez, K. S. Sree, K. J. Appenroth, H. Zhao, A. Widmer, M. Huber, S. Xu
The paper analyzes population genomes and epigenomes of Spirodela polyrhiza to show low genomic diversity and DNA methylation levels, with natural selection shaping asexual reproduction traits.
bioRxiv · Jul 18, 2023 · PreprintEvolutionary Biology
Y.-H. Lao, R. Ji, J. K. Zhou, K. J. Snow, N. Kwon, E. Saville, S. He, S. Chauhan, C.-W. Chi, M. S. Datta, H. Zhang, C. H. Quek, S. Cai, M. Li, Y. Gaitan, , K. W. Leong
This paper demonstrates a method to edit the brain genome in mammals using focused ultrasound to temporarily open the blood-brain barrier for CRISPR/Cas9 delivery via intravenous injection.
bioRxiv · Dec 10, 2022Bioengineering
J. Kim, A. Kratz, S. Chen, J. Sheng, L. Zhang, B. K. Singh, A. Chavez
This paper introduces HITAG, a method for high-throughput tagging of endogenous loci to study protein function, and demonstrates its use in analyzing stress granule-associated proteins.
bioRxiv · Nov 16, 2022Cell Biology
N. C. Gervais, A. A. La Bella, L. F. Wensing, J. Sharma, V. Acquaviva, M. Best, R. O. Cadena Lopez, M. Fogal, D. Uthayakumar, A. Chavez, F. Santiago-Tirado, A. L. Flores-Mireles, R. S. Shapiro
This paper develops a CRISPR activation system for genetic overexpression in Candida albicans and demonstrates its ability to drive high-level gene expression and identify novel phenotypes.
bioRxiv · Aug 15, 2022Microbiology
S. Iketani, H. Mohri, B. Culbertson, S. J. Hong, Y. Duan, M. I. Luck, M. K. Annavajhala, Y. Guo, Z. Sheng, A.-C. Uhlemann, S. P. Goff, Y. Sabo, H. Yang, A. Chavez, D. D. Ho
This study identifies multiple mutational pathways leading to nirmatrelvir resistance in SARS-CoV-2 through in vitro experiments and structural analysis.
bioRxiv · Aug 7, 2022Microbiology
S. Iketani, S. J. Hong, J. Sheng, F. Bahari, B. Culbertson, F. F. Atanaki, A. K. Aditham, A. F. Kratz, M. I. Luck, R. Tian, S. P. Goff, H. Montazeri, Y. Sabo, D. D. Ho, A. Chavez
This study maps the functional landscape of SARS-CoV-2 3CL protease by profiling all single mutants and identifies resistance mutations to nirmatrelvir.
bioRxiv · Jun 23, 2022 · PreprintMicrobiology
L. Liu, S. Iketani, Y. Guo, R. Casner, E. Reddem, M. S. Nair, J. Yu, J. Chan, M. Wang, G. Cerutti, Z. Li, C. Castagna, L. Corredor, H. Chu, S. Yuan, , D. D. Ho
The paper identifies a human monoclonal antibody that neutralizes all tested sarbecoviruses and describes a new antibody class with potential for pandemic preparedness.
bioRxiv · Dec 11, 2021 · PreprintMicrobiology
S. J. Resnick, S. Iketani, S. J. Hong, A. Zask, H. Liu, S. Kim, S. Melore, M. S. Nair, Y. Huang, N. E. S. Tay, T. Rovis, H. W. Yang, B. R. Stockwell, D. D. Ho, A. Chavez
This paper introduces a cell-based assay to identify coronavirus 3CL protease inhibitors without live virus, demonstrating its effectiveness through compound screening and structure-activity profiling.
bioRxiv · Aug 29, 2020 · PreprintMicrobiology
S. Iketani, F. Forouhar, H. Liu, S. J. Hong, F.-Y. Lin, M. S. Nair, A. Zask, Y. Huang, L. Xing, B. R. Stockwell, A. Chavez, D. D. Ho
The paper identifies three structurally diverse compounds as inhibitors of the SARS-CoV-2 3CL protease and provides structural insights for inhibitor design.
bioRxiv · Aug 3, 2020Microbiology