Author

H. R. Steach

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

R. A. Flavell· 2 shared A. Han· 1 shared A. Iwasaki· 1 shared A. Jarret· 1 shared A. Regev· 1 shared B. Israelow· 1 shared C. B. M. Porter· 1 shared C. B. Wilen· 1 shared

Activity by Year

2018-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersImmunology

R. A. Flavell

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Author profile →

2 papers

Recent·Most cited

Inflammasome activation in infected macrophages drives COVID-19 pathology

E. Sefik, R. Qu, C. Junqueira, E. Kaffe, H. Mirza, J. Zhao, J. R. Brewer, A. Han, H. R. Steach, B. Israelow, H. N. Blackburn, S. Velazquez, Y. G. Chen, S. Halene, A. Iwasaki, , R. A. Flavell

This study shows SARS-CoV-2 infection of human macrophages drives COVID-19 pathology through inflammasome activation, leading to inflammation and pyroptosis, but also enabling viral release.

bioRxiv · Sep 27, 2021Immunology

Skin inflammation driven by differentiation of quiescent tissue-resident ILCs into a spectrum of pathogenic effectors

P. Bielecki, S. J. Riesenfeld, M. S. Kowalczyk, M. C. Amezcua Vesely, L. Kroehling, P. Yaghoubi, D. Dionne, A. Jarret, H. R. Steach, H. M. McGee, C. B. M. Porter, P. Licona-Limon, W. Bailis, R. Jackson, N. Gagliani, , R. A. Flavell

The paper shows that psoriasis is driven by the reprogramming of quiescent skin-resident ILCs into pathogenic effectors through epigenetic and transcriptional changes.

bioRxiv · Nov 12, 2018Immunology